Based on the protective effect of the combined extract of purple waxy corn and ginger (PWCG) on oxidative stress related disorders in diabetic condition, we aimed to determine the effect of PWCG on the functional, biochemical, and structural change of the lesion nerve in streptozotocin- (STZ-) diabetic rats. PWCG at doses of 100, 200, and 300 mg·kg(-1) BW were orally given to STZ-diabetic rats ...

OBJECTIVE To investigate the effect of surgical decompression on painful diabetic peripheral neuropathy (DPN) patients and discuss the role which pain distribution and characterization play in the management of painful DPN as well as the underlying mechanism involved. METHODS A total of 306 patients with painful diabetic lower-extremity neuropathy were treated with Dellon surgical nerve decom...

Background: Organophosphates are among the most common causes of poisoning worldwide—responsible for 3 million and 200000 deaths every year. Nearly 15% people who poisoned die. This cross-sectional toxicological/clinical study aimed to investigate prevalence influential factors in incidence delayed peripheral neuropathy intermediate syndrome acute with organophosphorus toxins. The was conducted...

Although antibiotics (AB) are ineffective for the treatment of COVID-19, they often prescribed to patients with novel coronavirus infection (NCV) a variety reasons. They include difficulty excluding bacterial co-infection at first contact patient, as well possibility developing secondary infection. The aim work is assess frequency and background prescribing hospitalized confirmed COVID-19. Material ...

Presently, 151 widely-diverse pyridinylimidazole-based compounds that show inhibitory activities at the TNF-α release were investigated. By using the distance comparison technique (DISCOtech), comparative molecular field analysis (CoMFA), and comparative molecular similarity index analysis (CoMSIA) methods, the pharmacophore models and the three-dimensional quantitative structure-activity relat...

BACKGROUND The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. METHODS Experiments were carried out in Zucker diabetic fatty rats aged 10 wee...

OBJECTIVE Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted to investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats. RESEARCH DESIGN AND METHODS MSCs were isolated from bone marrow of adult rats and transplanted into hind limb skeletal muscles of rats wi...

Charcot-Marie-Tooth disease type 1A (CMT1A), the most frequent form of CMT, is caused by a 1.5 Mb duplication on the short arm of chromosome 17. Patients with CMT1A typically have slowed nerve conduction velocities (NCVs), reduced compound motor and sensory nerve action potentials (CMAPs and SNAPs), distal weakness, sensory loss and decreased reflexes. In order to understand further the molecul...

There have been many attempts for regeneration of peripheral nerve injury. In this study, we examined the in vivo effects of non-differentiated and neuronal differentiated adipose-derived stem cells (ADSCs) in inducing the neuronal regeneration in the Sprague-Dawley (SD) rats undergoing nerve defect bridged with the PCL nanotubes. Then, we performed immunohistochemical and histopathologic exami...