BACKGROUND Cutaneous anaesthesia in necrobiosis lipoidica (NL) has been attributed to the destruction of nerve fibres by the inflammatory process. In the 1980s, one study demonstrated a decrease in S100 positive neural fibres as proof of this. Thermalgic information is mainly dependent on small fibres, either myelinated or unmyelinated, and S100 protein is expressed by Schwann cells. OBJECTIV...

I tching or pruritus is an unpleasant sensation that evokes the desire or reflex to scratch. Itching in people with diabetes for the most part suggests a skin condition such as psoriasis, eczema, sunburn, athlete’s foot, hidradenitis suppurativa, pruritus vulvae from monilial infections, xerosis and diabetic eczema, necrobiosis diabeticorum, allergies to medications, drug eruptions, and many ot...

INTRODUCTION AND OBJECTIVES Necrobiosis lipoidica (NL) is a chronic idiopathic granulomatous disease considered to occur in association with diabetes mellitus. Data on the frequency of this association, however, are inconsistent. Our aim was to retrospectively analyze the clinical characteristics of patients diagnosed with NL at our hospital and to investigate the association with diabetes mell...