The patient, a 64-year-old man, with a past history of an IgM monoclonal gammopathy of undetermined significance (MGUS), presented with a 5-day history of ocular pain and redness in his left eye. The best-corrected visual acuity was conserved at 25/25 in both eyes. Topical instillation of phenylephrine did not blanch leading to the diagnosis of temporal anterior non-necrotizing scleritis (Figur...

AIM To detect the immunohistopathology of necrotising scleritis. METHODS Immunohistochemical staining was performed on two groups of enucleated eyes with necrotising scleritis (systemic autoimmune disease and idiopathic scleritis). Deparaffinised sections were stained with CD3, CD20, CD68, CD8, CD4 and dendritic reticulum cells (DRC). RESULTS Within the autoimmune group, about 43% of inflam...

BACKGROUND Scleritis is a potentially blinding inflammatory disorder. Standard care consists of systemic corticosteroids and immunosuppresants. The authors describe a series of 10 patients suffering from scleritis treated with the TNF inhibitor infliximab because this scleritis was refractory to standard therapy. METHODS The authors reviewed the medical records of patients with scleritis at the...

Purpose. To describe a case of anterior nodular scleritis, preceded by an anterior hypertensive uveitis, which was primarily caused by varicella zoster virus (VZV). Case Report. A 54-year-old woman presented with anterior uveitis of the right eye presumably caused by herpetic viral disease and was successfully treated. Two months later, she developed a nodular scleritis and started oral nonster...

Scleral inflammatory disease, a relatively common disease of the eye, is demonstrable on CT. Because of its unilateral and sometimes focal involvement, it may be mistaken for more serious diseases, both clinically and by CT. In particular, the clinical difficulties in diagnosing posterior scleritis have led to enucleations when such entities as melanoma and metastasis were suspected. We report ...

Thirty consecutive patients with severe scleritis or episcleritis were admitted as in-patients to the Medical Ophthalmology Unit and assessed for systemic disease. There were seventeen women and thirteen men. The mean age was 53 with a median of 57 (range 23-83). Eighteen of the patients had scleritis: eleven of these had evidence of connective tissue disease and three of them had temporal art...

BACKGROUND Stenotrophomonas maltophilia is a seldom-reported pathogen in ocular infections. The report describes six cases of Stenotrophomonas maltophilia (S. maltophilia) keratitis and scleritis. To our knowledge, this is the foremost report of S. maltophilia scleritis. METHODS Laboratory reports of patients diagnosed with S. maltophilia ocular infections were collected from the ophthalmic d...

PURPOSE The purpose of this study was to report outcomes of infectious scleritis after pterygium surgery, managed with antibiotic therapies and early scleral debridement. METHODS Retrospective chart review of 13 consecutive cases of infectious scleritis after pterygium excision between 1999 and 2009 was conducted. Collected data included prior medical and surgical history, latency period betw...

BACKGROUND There have been several published reports of inflammatory ocular adverse events, mainly uveitis and scleritis, among patients taking oral bisphosphonates. We examined the risk of these adverse events in a pharmacoepidemiologic cohort study. METHODS We conducted a retrospective cohort study involving residents of British Columbia who had visited an ophthalmologist from 2000 to 2007....