Vitex negundo L. (Verbenaceae) is a hardy plant, flourishing mainly in the Indian subcontinent. All parts of the plant, from root to fruit, possess a multitude of phytochemical secondary metabolites which impart an unprecedented variety of medicinal uses to the plant. It is interesting to note that a single plant species finds use for treatment of a wide spectrum of health disorders in traditio...

Tail flick test in rats and acetic acid induced writhing in mice were employed to study the antinociceptive activity of ethanolic leaf extract of Vitex-negundo (VN) (100, 250 and 500 mg/kg, p.o). The effect was compared with meperidine (40 mg/kg, sc) in tail flick method and aspirin (50 mg/kg, p.o) in writhing test as a standard control respectively. An interaction with naloxone hydrochloride w...

The leaves of Acer negundo L. var. odessanum (H. Rothe), if permanently exposed to strong sunlight, do not green, but remain yellow and finally become bleached. In yellow leaves the plastids contain single thylakoids and no grana. In plastids of bleached leaves, however, only vesicles are present. The concentration of chlorophylls and photosynthetic activity are much lower in those leaves than ...

In the present study three medicinal plants Vitex negundo Linn (Verbenaceae), Bryophyllum pinnatum Linn (Crassulaceae) and Centella asiatica (Umbelliferae) reported to have significant analgesic potential were selected to be formulated as polyherbal gels with and without permeation enhancers and were investigated for their antinociceptive potential. The dried finely ground herbs were extracted ...