Therapies for heart disease are based largely on our understanding of the adult myocardium. The dramatic differences in action potential (AP) shape between neonatal and adult cardiac myocytes, however, indicate that a different set of molecular interactions in neonatal myocytes necessitates different treatment for newborns. Computational modeling is useful for synthesizing data to determine how...

Abstract Critical congenital heart diseases (CCHD) are important causes of mortality and morbidity in the newborn period. Even after diagnosis, their management could be seriously compromised by unplanned delivery hospitals with limited expertise resources. The may spend days or week before transport putting a significant burden on neonatal team to manage such challenging diseases. In this revi...

how to cite this article: islami z, ataee nakhaei mh. neurological manifestations of an old disease: a case report. iran j child neurol. 2013 summer; 7(3): 55-57.   objective neurological manifestations of neonatal disorders have various causes, among them neonatal tetanus, albeit rare, is a potentially fatal and preventable disease, which is seen in underdeveloped and developing countries. alt...

Transportation of sick neonates under controlled conditions has a direct relationship with morbidity and mortality(l). Poor transportation is one of the iatrogenic factors significantly associated with greater neonatal mortality(2). Attention is now being paid to intra-hospital transport of babies. However, care during referral to hospital is largely a neglected field in India and no documentat...

Neonatal Lupus Erythematosus (NLE) is a rare disease associated with placental transport of maternal anti-Ro/La and/or anti-U1RNP antibodies into the fetal circulation and characterized by cardiac, cutaneous, hematologic and hepatic manifestations. The most serious complication of NLE is complete heart block and cardiomyopathy. The maternal connective tissue disorder has been systemic lupus ery...

OBJECTIVES Studies on factors affecting neonatal mortality have rarely considered the impact of place of delivery on neonatal mortality. This study provides epidemiological information regarding the impact of place of delivery on neonatal deaths. METHODS We analyzed data from the Rufiji Health and Demographic Surveillance System (RHDSS) in Tanzania. A total of 5,124 live births and 166 neonat...

Despite declines in globalmortality rates in infants and children under five years of age in recent decades, neonatalmortality has remained relatively static. Consequently, approximately twothirds of deaths in infants and over one-third of deaths in under-five-year-olds now occur in the first 28 days of life (i.e., the neonatal period). There are an estimated four million neonatal deaths per ye...

background: neonatal deaths mostly occur within the first one week and first 24 hours of life from a variety of conditions. objective: to examine the role of significant hypothermia and hypoglycaemia, in addition to some other factors, in neonatal mortality occurring within the first 24 hours of admission.methods: a prospective study of newborn infants hospitalized within the first 24 hours of ...

Genetic evidence supports a critical role for the epithelial sodium channel (ENaC) in both clearance of fetal lung liquid at birth and total body electrolyte homeostasis. Evidence from heterologous expression systems suggests that expression of the alphaENaC subunit is essential for channel function, whereas residual channel function can be measured in the absence of beta or gamma subunits. We ...

INTRODUCTION Neonatal imaging is of growing importance as the effects of premature birth are becoming better controlled and babies are surviving from earlier gestational ages. Prematurity can often lead to consequences for the CNS and other parts of the body and MR is highly relevant for imaging this population as it is non-invasive and so allows follow up scanning. There have been two main app...