Leydig cell tumor as a sex-cord stromal tumor is a relatively uncommon ovarian tumorin bitch. A 10-year-old female German Shepherd dog was presented because of protrusion of a large tumor-like mass of 16 × 14 × 7 cm in dimensions from her vagina. After stabilization of the patient, the mass was removed surgically and concurrent ovariohysterectomy was also performed. Macroscopically, the healthy...

Follicular helper T-cell (TFH) lymphomas comprise a unique group of that represent neoplastic proliferations follicular T-cells and share genetic, immunophenotypic, morphologic, clinical features. Angioimmunoblastic lymphoma (AITL) is the prototypical TFH lymphoma; in addition, 2017 revised World Health Organization (WHO) 4th edition recognizes two other subtypes: (FTCL) nodal peripheral with T...

The degradation of subendothelial and smooth muscle matrices by normal and neoplastic uroepithelial cells grown under serum-free conditions was examined. Normal urothelial cells were compared with neoplastic cells derived from a low grade papillary tumor (RT4) and a more invasive carcinoma (EJ). Low levels of degradation were observed with all cell types in serum-free medium alone. Supplementin...

Specific regulatory pathways in neoplastic cells seem to be responsive to control signals provided by the normal cell/tissue environment. The pres ent experiments were designed to doline, at the molecular level, the growth-regulatory signals in neoplastic cells that are associated with the modulation of expression of the neoplastic phenotype by normal cell populations. When cultured in the pres...