Chronic kidney disease (CKD) is a global problem all over the world. Special attention is paid to the action of natural compounds. This research was aimed to investigate the effect of complex phytochemical preparation (Herba centaurii, Radix levistici and Folia rosmarini) on dynamics of morphological changes in kidney tissue in animals with glomerulonephritis. We found a positive dynamics in th...

conclusions in our study, hydroalcoholic extract of cyperus scariosus linn. offered nephroprotection in the form of aki prevention and for the treatment of established aki. results serum creatinine was significantly increased (p < 0.05) while 24 hours urine output, urine creatinine, and serum protein were significantly decreased (p < 0.05) in rats treated with gentamicin as compared to the cont...

Incretin-based therapies represent one of the most promising options in type 2 diabetes treatment owing to their good effectiveness with low risk of hypoglycemia and no weight gain. Other numerous potential beneficial effects of incretin-based therapies have been suggested based mostly on experimental and small clinical studies including its beta-cell- and vasculo-protective actions. One of the...

Ischemia/Reperfusion (I/R) injury during kidney transplantation is a major clinical problem which leads to delayed graft function or even graft rejection. Therefore, the aim of the present study was to explore the possible protective effects of trimetazidine, an anti-ischemic agent, against experimentally-induced renal I/R injury in rats. Ischemia was induced by bilateral clamping of renal pedi...

Abstract Background Homeostatic regulation of cardiomyocytes is indispensable in maintaining the normal physiological activity cardiac tissue. Cardiotoxicity induced by drugs may lead to abnormalities such as arrhythmia, myocardial infarction and hypertrophy. Moreover, drug-induced cardiotoxicity confines additional use implicated drugs. Several studies have reported that consumption phytochemi...