Protection against diabetic nephropathy (DN) is one of the main targets in diabetes treatment and present study evaluates the nephroprotective effect of Carica papaya L. in streptozotocin (STZ) induced diabetic rats. DN rats were treated with 1.5 and 2.5 gm/dl C. papaya leaf extract for 6 weeks to determine its nephroprotective effect with different parameters. Pimagedine (1 ml/mg) served as a ...

Chronic kidney disease (CKD) is a global problem all over the world. Special attention is paid to the action of natural compounds. This research was aimed to investigate the effect of complex phytochemical preparation (Herba centaurii, Radix levistici and Folia rosmarini) on dynamics of morphological changes in kidney tissue in animals with glomerulonephritis. We found a positive dynamics in th...

Diacylglycerol (DAG) has been reported to reduce the serum lipid and glucose levels more effectively compared with triacylglycerol (TAG). The present study examined the long-term effects of dietary DAG on rats with type 2 diabetic nephropathy (DN). The type 2 DN model was established by administering a high-fat and high-calorie diet along with an intraperitoneal injection of 35 mg/kg body weigh...

Although cisplatin is an anticancer drug that has activity against malignant tumor, it often causes nephrotoxicity. Previous reports have confirmed that the saponins from the leaves of P. quinquefolium (PQS) exerted many pharmacological activities. However, the renoprotective effects of PQS were still unknown. The purpose of the present research was to discuss renoprotective effect of PQS in a ...

Lead (Pb) is a toxic heavy metal that causes kidney injury and oxidative tissue damage. Current drugs to treat nephrotoxicity have multiple side-effects. Therefore, the development of novel therapeutic approaches urgently required. We investigated nephroprotective efficacy flaxseed lignan secoisolariciresinol diglucoside (SDG) against lead acetate (PbAc)-induced renal toxicity in rats. The acti...

Fabry's Disease is a rare genetic syndrome, with a classic X-linked alpha -galactosidase A deficiency phenotype, responsible for glico-sphyngolypids metabolism impairment with clinical effects in several organs and functions. We describe the anaesthesiologic implications of two patients with Fabry disease who underwent a kidney transplantation from a deceased donor. We recommend careful preoper...