Researchers investigated whether antipsychotic drugs were associated with venous thromboembolism. A population based nested case-control study design was used. Data were taken from the UK QResearch primary care database consisting of 7 267 673 patients. Cases were adult patients with a first ever record of venous thromboembolism between 1 January 1996 and 1 July 2007. For each case, up to four ...

Nested case-control designs (or equivalently, incidence density sampling designs) are are a common approach for reducing the costs the costs of exposure assessment in a prospective epidemiologic study. Exposure data are obtained from all cases and a pre-specified number of controls randomly chosen at each failure time from all subjects who had entered the study but had not failed or left it yet...

OBJECTIVE Although numerous studies have found higher rates of abortion and still births following consanguinity (familial marriages), the question of whether consanguinity significantly increases the risk of neonatal death has inadequately been addressed.This study aims to evaluate familial marriage effects on neonatal death in rural areas in Iran. MATERIALS AND METHODS In this nested case-c...

BACKGROUND The nested case-control design can be a very efficient approach to an epidemiological investigation. In order to obtain unbiased estimates of relative risk, controls should be selected by incidence density sampling, which involves matching each case to a sample of those who are at risk at the time of case occurrence. METHODS This paper presents a simple computer program for inciden...

In a nested case-control study, controls are selected for each case from the individuals who are at risk at the time at which the case occurs. We say that the controls are matched on study time. To adjust for possible confounding, it is common to match on other variables as well. The standard analysis of nested case-control data is based on a partial likelihood which compares the covariates of ...

Andersen et al. (1985, Biometrics 41, 921-932) gave an estimator of the cumulative relative mortality comparing rates of death in an epidemiologic cohort to an external population as a function of time when covariate information is available on all cohort members. We present an analogous estimator when covariate information is known only on a nested case-control sample. Counting process techniq...

Nested case-control (NCC) design is a popular sampling method in large epidemiological studies for its cost effectiveness to investigate the temporal relationship of diseases with environmental exposures or biological precursors. Thomas' maximum partial likelihood estimator is commonly used to estimate the regression parameters in Cox's model for NCC data. In this article, we consider a situati...

OBJECTIVES To determine the incidence of neonatal dehydration leading to rehospitalization, whether clinical and health services data could predict its occurrence, and the outcome of dehydrated infants. METHODS We employed a retrospective case-control design nested within a cohort of 51 383 newborns weighing 2000 g or more, with a gestational age of 36 weeks or more born at 11 Kaiser Permanen...

2 Transaction Approach 47 2.1 A Design Task Example . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 2.2 Compatibility Set Approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 2.3 Constraint-Based Approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 2.3.1 Intuitive Model of CAD Transaction . . . . . . . . . . . . . . . . . . . ...