Based on a large-scale neural network model of striate cortex (V1), we present a simulation study of extra- and intracellular response modulations for drifting and contrast reversal grating stimuli. Specifically, we study the dependency of these modulations on the neural circuitry. We find that the frequently used ratio of the first harmonic to the mean response to classify simple and complex c...

During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this timed cell genesis, with a particular focus on the developing cortex. These stud...

Understanding how genes influence behavior, including sexuality, is one of biology's greatest challenges. Much of the recent progress in understanding how single genes can influence behavior has come from the study of innate behaviors in the fruit fly Drosophila melanogaster. In particular, the elaborate courtship ritual performed by the male fly has provided remarkable insights into how the ne...

Interest in the effects of early adversity on children's development reflects contemporary emphases on early experience in the behavioral sciences and plasticity in the neurosciences. Over the past decade, powerful new tools and approaches for understanding the neural circuitry involved in emotion have become increasingly available. Yet, research in developmental psychopathology has not reaped ...

We present a novel platform to facilitate the growth of applied quantum information processing for neural circuitry, neural stimulation, and cognitive engineering. Cognitive computation has historically been studied by rich metaphors of language constructs, computational models for information processing, and semantic interpretations. Cortical interactions at the cellular and sub cellular level...

The primary somatosensory cortex (SI) is important for hand function and influences motor circuitry in the primary motor cortex (M1). Areas 3a, 1 and 2 of SI have direct connectivity with M1. Much of our present knowledge of this connectivity and its relevance to hand function is based on animal research. However, less is known about the neural mechanisms that underpin hand function in humans. ...