نتایج جستجو برای: neural differentiation
تعداد نتایج: 515348 فیلتر نتایج به سال:
OBJECTIVES Studies have confirmed that microgravity, as a mechanical factor, influences both differentiation and function of mesenchymal stem cells. Here we investigated the effects of simulated microgravity on neural differentiation of human adipose-derived stem cells (ADSCs). MATERIALS AND METHODS We have used a fast rotating clinostat (clinorotation) to simulate microgravity condition. Rea...
The canonical Wnt/Wingless pathway is implicated in regulating cell proliferation and cell differentiation of neural stem/progenitor cells. Depending on the context, β-Catenin, a key mediator of the Wnt signaling pathway, may regulate either cell proliferation or differentiation. Here, we show that β-Catenin signaling regulates the differentiation of neural stem/progenitor cells in the presence...
The Role of Glycoconjugates in Development of Floor Plate During Early Morphogenesis in Mouse Embryo
The floor plate is a small group of cells located at the ventral midline of neural tube. During early neurogenesis the floor plate plays critical role (s) in differentiation of ventral portion of neural tube.The purpose of this study was to determine the distribution of glycoconjugates in floor plate as well as underlying mesoderm (notochord) and their inductive activities in mouse embryos.Form...
Neural precursors persist throughout life in the rodent forebrain subventricular zone (SVZ) and hippocampal dentate gyrus. The regulation of persistent neural stem cells is poorly understood, in part because of the lack of neural progenitor markers. The Sox B1 subfamily of HMG-box transcription factors (Sox1-3) is expressed by precursors in the embryonic nervous system, where these factors main...
Formation of the metazoan body plan requires a complex interplay of morphological changes and patterning, and central to these processes is the establishment of apical/basal cell polarity. In the developing nervous system, apical/basal cell polarity is essential for neural tube closure and maintenance of the neural stem cell population. In this report we explore how a signaling pathway importan...
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