نتایج جستجو برای: neuregulin
تعداد نتایج: 1675 فیلتر نتایج به سال:
Neuregulins (NRGs) comprise a large family of EGF-like signaling molecules involved in cell-cell communication during development and disease. The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4. Relatively little is known about the biological functions of the NRG2, 3, and 4 proteins. In contrast, the NRG1 proteins have been demonstrated to play important roles during ...
BACKGROUND The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, the molecular alterations in brain Nrg1 expression that underpin the behavioural observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA Nrg1 trans...
Subject: Polycystic ovary syndrome (PCOS) is female disorder caused by cysts formation in ovarian that results of hormones secretion and menstrual cycle. Neuregulin 4 (NRG4) one adipokines family members synthesis release via adipose tissues, it acts as activator the epidermal growth factor receptor (EGFR).Objective Study: Assessment role NRG4 PCOS patients.Materials Methods: Present study incl...
Trastuzumab emtansine (T-DM1) represents a significant advancement in the treatment of HER2(+) breast cancers. Its clinical efficacy however will be limited by the development of therapeutic resistance. In this report, the HER3 ligand neuregulin is shown to mediate T-DM1 resistance, which was overcome by administration of pertuzumab, a steric inhibitor of HER2 dimerization.
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