Pancreatic neuroendocrine tumors (pNET) are a rare malignancy. Many patients will present with metastatic disease most commonly to the liver. Currently the standard of care for treatment of liver metastases from neuroendocrine tumors (NETs) is surgical resection. However, only few patients are candidates for surgical resection and require alternative options. Given the rarity of this disease; d...

AIMS To compare the density of neuroendocrine cells in rectal biopsy specimens from human immunodeficiency virus (HIV) infected individuals with that of a control group. METHODS Neuroendocrine cells in rectal biopsies were identified using an immunohistochemical stain for chromogranin and subsequently quantified using a method of linear intercept. RESULTS Neuroendocrine cells were found to ...

Context The neuroendocrine tumor of the ampulla of Vater represents a rare disease and, although the majority of them are indolent, this neoplasm has a relatively poor prognosis. A quarter of cases of ampullary neuroendocrine tumors have been detected in patients with neurofibromatosis type I (von Recklinghausen's disease). The biological behavior of ampullary neuroendocrine tumor shows no asso...

Neuroendocrine tumour of breast is an extremely rare condition. It may present as focal neuroendocrine differentiation with other histological subtypes of breast cancer or primary neuroendocrine tumour of breast or a metastatic foci in breast. There are no radiologic or clinical signs specific to this subtype. With rarity of its occurrence and absence of randomised trials regarding neuroendocri...

Neuroendocrine tumors (NETs) can be found in most organs, as well as in the urinary bladder. Some of the clinical and pathologic features of these tumors may be characteristic of the organ of origin, but most of the properties are shared by neuroendocrine neoplasms regardless of their anatomic site. In the bladder, NETs comprise less than 1% of all bladder tumors and can be found in a pure form...

Background. It has been shown before that drinking mineral waters of different composition a significant effect on the neuroendocrine, metabolic and immune parameters healthy rats. We analyzed canonical correlations between neuroendocrine parameters, one hand, other hand. Materials Methods. Experiment was performed 58 female Wistar rats 240-290 g. HRV major adaptation hormones, metabolism immun...

PURPOSE The neuroendocrine phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the neuroendocrine phenotype in CRPC. EXPERIMENTAL DESIGN Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and prostate-specific antigen (PSA) was analyzed by IHC in 155 C...

Neuroendocrine carcinomas are rare tumors. In the head and neck region they are most common in the larynx, where they represent 0.5-1% of epithelial cancers. Diagnosis requires the recognition of the typical neuroendocrine architecture and morphology and the immunohistochemical confirmation of neuroendocrine differentiation. In the 1991 WHO classification laryngeal neuroendocrine carcinomas hav...

Lung cancer encompasses a constellation of malignancies with no validated prognostic markers. p16Ink4A expression has been reported in different subtypes of lung cancers; however, its prognostic value is controversial. Here, we sought to investigate the clinical significance of p16Ink4A immunoexpression according to specific staining patterns and its operational implications. A total of 502 tum...

Neuroendocrine lung cancer is among the most common types of lung cancers in smokers. We have recently shown that exposure of hamsters to N-nitrosodiethylamine and hyperoxia causes a high incidence of this tumor type. In this study, we show that the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone also causes neuroendocrine lung tumors in hyperoxic hamsters. Animals m...