نتایج جستجو برای: neuroinflammation
تعداد نتایج: 6975 فیلتر نتایج به سال:
The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important r...
Schizophrenia is a chronic debilitating mental illness. In many aspects, the neuropathology of schizophrenia closely associated with neuroinflammation, especially microglial activation. Microglial hyperactivity, which characterized by predominant release proinflammatory cytokines serves as basis neuroinflammation hypothesis in schizophrenia. The enhanced inflammatory induce neuronal susceptibil...
calcineurin (can) is a ca2+/calmodulin (ca2+/cam)-dependent serine/threonine protein phosphatase expressed in most mammalian tissues but found at higher concentration in brain. in the last decade there have been a steadily increasing number of studies identifying neuronal can as a primary suspect in neuronal vulnerability, synapse loss, dendritic atrophy, synaptic dysfunction and neuroinflammat...
Abstract Purpose of Review The current review aims to explore recent studies that have illustrated a link between neuroinflammation and tinnitus the consequential effect on neuronal functioning. We parallels amongst pain pathologies novel treatment option. Recent Findings Genetic pharmacological blockage pro-inflammatory cytokines mitigates physiological behavioral phenotype in acute rodent mod...
Cyclooxygenase (COX) expression in the brain is associated with pro-inflammatory activities, which are instrumental in neurodegenerative processes such as Parkinson's disease (PD). It is discussed that drugs with the capacity to rescue dopaminergic neurons from microglia toxicity and neuroinflammatory processes may result in an amelioration of parkinsonian symptoms by delaying the onset or slow...
Abstract The human neurovascular system is a complex network of blood vessels and brain cells that essential to the proper functioning brain. Researchers have become increasingly interested in for developing drugs treat neuroinflammation. Currently, creating models begins with animal models, followed by testing on humans clinical trials. However, high number medication failures pass through ind...
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