Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection. Using mRNA-seq analysis of HA1800-control cells with HA1800-HHV-6A G...

SARS-CoV-2, a new virus, which has been causing the catastrophic pandemic in world 2020, triggers numerous physiologic changes humans, with potentially fatal evolution due to COVID-19. COVID-19 can trigger immunoparalysis deep and silent immunosuppression state of tolerance that may elicit opportunities for neoplastic transformation or latent infectious diseases. In addition, all neurologic psy...

conclusions these finding showed that dysport can be significantly effective in reducing the amount of saliva for 18 weeks. results in this study, the effect of dysport on the amount of drooling of the participants at the sixth, 12th, and 18th weeks after treatment was significantly decreased (p value of 0.00016, 0.0001, and 0.00011, respectively). however, after 24 weeks, this difference was n...

sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...

treatment recommendations can be offered. Some spinal neurologic diseases, such as many of the spinal degenerative disorders, either are not treatable or have no globally accepted treatment. For those diseases with established treatments, general treatments include either non-surgical (medical) or surgical treatments. Rehabiliation, physical therapy, and pain management are also important aspec...

chronic brain diseases in which ordered protein polymerization is endogenously seeded. A detailed understanding of this process may shed new light on the etiology of these diseases, allow risk factors to be identified, and pave the way for more effective and specific Peter T. Lansbury, Jr. Center for Neurologic Diseases Brigham and Women’s Hospital Department of Neurology Harvard Medical School...

Take home points: 1. Classic Guillain-Barré syndrome (GBS) presents as a rapidly progressive, ascending paralysis with distal areflexia and a mild sensory deficit. 2. We now know that GBS represents a spectrum of neurologic diseases with a common theme: rapidly progressive, symmetric neurologic injury that is due to immune dysregulation (molecular mimicry). 3. Think of GBS any time you have a p...

Many of the congenital neurologic diseases can result in incapacity or death of the animal. Some of them, such as idiopathic epilepsy and hydrocephalus, exhibit breed or familial predisposition and a genetic basis was proved or suggested. Some diseases can be presumptively diagnosed after a detailed signalment (breed predisposition), history (e.g. family history because many of these defects ha...

BACKGROUND Neurologic disorders represent a major burden of disease globally and the spectrum ranges from noncommunicable disorders like stroke and neurodegenerative disorders to central nervous system infections. OBJECTIVE The purpose of the study is to assess the burden of neurological diseases in a tropical environment. METHODS A one year retrospective survey of neurological diseases see...