نتایج جستجو برای: neuroregeneration
تعداد نتایج: 305 فیلتر نتایج به سال:
the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...
The fat mass and obesity-associated protein (FTO), an RNA N6-methyladenosine (m6A) demethylase, is important regulator of central nervous system development, neuronal signaling disease. We present here the target-tailored development biological characterization small-molecule inhibitors FTO. active compounds were identified using high-throughput molecular docking dynamics screening ZINC compoun...
Freshwater planarians, famous for their regenerative prowess, have long been recognized as a valuable in vivo animal model to study the effects of chemical exposure. In this review, we summarize the current techniques and tools used in the literature to assess toxicity in the planarian system. We focus on the planarian's particular amenability for neurotoxicology and neuroregeneration studies, ...
BACKGROUND AND PURPOSE Stroke remains a common medical problem with importance attributable to the demographic changes in industrialized societies. SUMMARY OF REVIEW After years of setbacks, acute stroke therapy has finally emerged, including thrombolysis with tissue plasminogen activator (t-PA). However, t-PA treatment is limited by a narrow time window and side effects, so that only 3% of a...
63 64 65 66 67 68 69 70 71 72 73 74 75 76 Michael S. Unger, Julia Marschallinger, Julia Kaindl, Barbara Klein, Mary Johnson, Ahmad A. Khundakar, Stefan Roßner, Michael T. Heneka, Sebastien Couillard-Despres, Ed Rockenstein, Eliezer Masliah, Johannes Attems, Ludwig Aigner* Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria Spinal Cord Injury and Tissue...
At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC), which are potentially able to replace dead cells and synthesize neurotrophic factors and other molecules tha...
There is a great need for pharmacological approaches to enhance neural progenitor cell (NPC) function particularly in neuroinflammatory diseases with failed neuroregeneration. In diseases such as multiple sclerosis and stroke, T-cell infiltration occurs in periventricular zones where NPCs are located and is associated with irreversible neuronal loss. We studied the effect of T-cell activation o...
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