Introduction and Purpose. Information about myelin can be obtained indirectly from magnetization-transfer (MT) experiments . Quantification of MT imaging has been done by many researchers using a two-pool (binary spin-bath) model consisting of a free water pool “a” and a semi-solid, macromolecular pool “b” . Integral part of this model is a lineshape describing the absorption probability of the...

Introduction: Brain iron is believed to play a role in pathophysiology of neurodegenerative processes. Increased iron levels in certain regions of the brain have been reported in various diseases including Alzheimer`s and Parkinson`s disease or multiple sclerosis as well as TBI or ageing [1, 2]. Numerous publications have investigated whether non-invasive assessment of brain iron is possible by...

•Heterocellular spheroids of the NVU are biofabricated by a simple method•Heterocellular express key structural and functional proteins BBB•RNA-Seq analysis confirmed high expression endothelial cell-specific genes•Nanoparticles enter spheroid, likely activated microglia astrocytes Nanoneuromedicine investigates nanotechnology to target brain treat neurological diseases. In this work, we hetero...

Within drug discovery, it is desirable to determine whether a compound will penetrate and distribute within the central nervous system (CNS) with the requisite pharmacokinetic and pharmacodynamic performance required for a CNS target or if it will be excluded from the CNS, wherein potential toxicities would mitigate its applicability. A variety of in vivo and in vitro methods for assessing CNS ...

Stroke patients are at a higher risk of developing progressive cognitive impairment, often retarding patient rehabilitation. Studies have been carried out to find out the molecular mechanism associated with the stroke and its consequences on the various brain regions implicated in cognitive function. The current available therapy does not improve longterm outcome and remains a substantially unm...

Metadoxine (pyridoxol L-2-pyrrolidone-5-carboxylate) is an ion-pair salt of pyridoxine (vitamin B6) and 2-pyrrolidone-5-carboxylate (PCA, also known as L-PGA). Metadoxine modulates GABAergic activity, and does not increase levels of brain neurotransmitterssuch as dopamine, norepinephrine and serotonin. In animal studies, Metadoxine has shown no signs of abuse or addiction potential....

how to cite this article: soltani d, ghaffar pour m, tafakhori a, sarraf p, bitarafan s. nutritional aspects of treatment in epileptic patients. iran j child neurol. summer 2016; 10(3): 1-12.   abstract epilepsy is a neurological disorder characterized by interruption of normal neuronal functions that is manifested by behavioral disorders, changing of awareness level, and presence of some senso...