There are at least two pathways driving cutaneous melanoma; one is linked to an inherent melanoma susceptibility to nevi development and the second to environmental cumulative ultraviolet light exposure. In this study, we examined the relation between nevus density, accrued sun damage and the site of primary melanoma excision. In a series of 888 consecutive cutaneous melanoma patients, melanoma...

In a recent two-part essay entitled “The dysplastic nevus: from historical perspective to management in the modern era” published in the Journal of American Academy of Dermatology, Duffy and Grossman concluded, following comprehensive literature review, historically, histologically, clinically and molecularly, that the so-called dysplastic nevus is a type of melanocytic nevus and should be mana...

Eccrine nevus is a rare skin lesion with protean manifestations like hyperhidrosis, discolored nodules, papules, and so forth, which has been reported in various anatomic parts of the body including the forearm, leg, thigh, back, and coccyx. Our patient was a 26-year-old male, who presented with increasing colorless and odorless episodic umbilical discharge. First impression for the patient was...

Prostate gland is an unusual location for melanocytic lesions such as blue nevus. Typically, all three different types of melanchromatic lesions in the prostate, blue nevus, melanosis and malignant melanoma, are very rare and must be differentially diagnosed. These lesions are incidental findings in prostatic tissue biopsies and have a potential correlation with prostate adenocarcinoma. Blue ne...

patientwith Becker nevus of the lower limb. Subsequently, 11 more cases of Becker nevus of the leg have been reported.4 In 2 patients, the reports explicitly noted the absence of hypertrichosis. In 2 female patients, Becker nevus was associated with localized lipoatrophy: a 14-year-old girl with a softtissue defect on the ventral aspect of her thigh and a 45-yearoldwomanwith lipoatrophyon the r...

Nine halo nevi in various stages of regression were examined by electron microscopy for fine structural evidence of an immunological mechanism of tumor cell destruction and halo formation. Early regressing lesions (Stage I) showed nevus cells associated with infiltrating lymphocytes, monocytes, and plasma cells, but without nevus cell destruction. In later lesions (Stages II and III), vacuolar ...

Phacomatosis pigmentovascularis is a rare, congenital condition characterized by a combination of cutaneous melanocytic lesions and vascular malformation. We discuss an entirely unique case of Phacomatosis pigmentovascularis with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita, which may represent a heretofore undescribed vari...

Several dermatoses have been reported in association with Becker's nevus. Eczematous dermatitis associated with Becker's nevus is extremely rare, described in only two previous case reports. We report a case of 21-year-old male with recurrent eczema lesions which were always localized within the underlying Becker's nevus lesion. This case may be explained as a Wolf's isotopic response-like phen...

Reed nevus or pigmented spindle-cell nevus may mimic cutaneous melanoma; however, its dermoscopic and histopathological characteristics are different. This case report describes three patients with distinct clinical, dermoscopic and histopathological presentations, which were correlated to enable a differential diagnosis to be made between melanoma and Spitz nevus.

BACKGROUND The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure. OBJECTIVES We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions. METHODS Digitalized images of skin lesions from 679 patients with histopathological dia...