Purpose: This article describes the preparation and characterization of folate conjugated nanoparticles using poly(lactide-co-glycolide)-poly(ethylene glycol)-folate (PLGA-PEG-FOL) polymer for targeted delivery of anticancer agents. Methods: PLGA-PEG-FOL was synthesized by coupling di-block copolymer (PLGA-PEG-NH2) with folic acid. PLGA-PEG-FOL polymer was characterized by 1H NMR, GPC and FTIR....

Responses of growth hormone (GH) release to synthetic human growth hormone-releasing factor (hGRF)-44-NH2 analogs were determined, and the GH-releasing potency based on dose per kg of body weight (bw) was compared with that of hGRF-44-NH2 in female dairy calves. Four- and 12-month-old calves were injected intravenously with 0.25 microgram of hGRF-44-NH2 or its analogs per kg of bw. Blood sample...

Water contaminated with low concentrations of pollutants is more difficult to clean up than that high pollutant content levels. Membrane separation provides a solution for removing from water. However, membranes are prone fouling, losing performances over time. Here we synthesized neutral (IM-NH2) and positively charged (IL-NH2) imidazole derivatives chemically functionalize membranes. With dis...

Nanoflowers and nanospheres of Pd4S have been prepared for the first time from a single source precursor complex, [PdCl2(PhS-CH2CH2CH2-NH2)] (), by its one pot thermolysis at 195 °C. In oleylamine, flower shaped nanoparticles of Pd4S were formed but in an oleic acid (OA) and octadecene (ODE) mixture (1 : 1) the product was nanospheres of Pd4S (size in the range ∼23-38 nm and 15-28 nm, respectiv...

The selective oxidation of styrene with highly efficient, environmentally benign, and cost-effective catalysts are great importance for sustainable chemical processes. Here, we develop an in situ self-assembly strategy to decorate Cu-based metal-organic framework (MOF) Cu-BDC-NH2 nanocrystals on Cu2O octahedra construct a series Cu2O@Cu-BDC-NH2 styrene. Using H2O2 as green oxidants, the optimiz...

Organic dyes can enter water bodies through industrial wastes and may pose a threat to the health of aquatic organisms human. Metal organic framework derived carbon materials (CMOFs) have shown excellent performance for aqueous dye adsorption. However, few studied multimetallic CMOFs removal. Herein, ternary metal oxide embedded from amino-modified (CMOF(Fe/Al/Ni 8/7/5)-NH2) has been developed ...

The intrinsic conformational preferences of small peptides may provide additional insight into the thermodynamics and kinetics protein folding. In this study, we explore underlying energy landscapes two model peptides, namely, Ac-Ala-NH2 Ac-Ser-NH2, using geometry-optimization-based tools developed within context landscape theory. We analyze not only how side-chain polarity influences structura...

Using naturally serum-free SU-ECM basement membranes as invasion substrates showed that plasma fibronectin was necessary to stimulate invasion by DU 145 human and metastatic MATLyLu (MLL) rat prostate carcinoma cells. This activity mapped to the PHSRN sequence, which induced invasion through alpha5beta1 integrin. PHSCN, a competitive inhibitor, blocked both PHSRN- and serum-induced invasion. Ac...