The pleiotropic cytokine interleukin-6 (IL-6) has been proposed to contribute to circadian regulation of sleepiness by increasing in the blood at night. Earlier studies have reported diurnal variation of IL-6, but phase estimates are conflicting. We have therefore performed a meta-analysis on the diurnal variation of circulating IL-6. Studies were included if they reported IL-6 in plasma or ser...

Purpose The diurnal cycling of intraocular pressure (IOP) was first described in humans more than a century ago. This cycling is preserved in other species. The physiologic underpinning of this diurnal variation in IOP remains a mystery, even though elevated pressure is indicated in most forms of glaucoma, a common cause of blindness. Once identified, the system that underlies diurnal variation...

Freshwater and hypersaline lakes in arid semi-arid environments are crucial from agricultural, industrial, ecological perspectives. The purpose of this paper was to investigate the effect salinity on evaporation water surfaces. main achievement research is successful capture simulated climate–surface interactions prevalent Canadian Prairies using a custom-built bench-scale atmospheric simulator...

NIGHT blindness has been known since the time of -the ancient Egyptians and was described by Hippocrates in the second book of Prorrhetics. One thousand years after Hippocrates, the beneficial effects of liver on night blindness were described by the Byzantine physician Paulus Aegineta. Rhazes recognized no less than three varieties (Holcomb, 1934). Richerand described an unrecognized occupatio...

the purpose of this study was to conduct a quantitative risk assessment for pah exposure forconsumers at a night market in taiwan. the major methods assessed potential risk under different exposure scenarios based on bap equivalent concentration (bapeq) and incremental lifetime cancer risk (ilcr) models. we performed experimental sampling at a night market from 27 october through 22 november 20...

Nicotine is the major addictive compound in tobacco and is responsible for tobacco dependence. It is primarily metabolized to cotinine (COT) and trans-3'-hydroxycotinine (3HC) by the liver enzyme cytochrome P-450 2A6 (CYP2A6). The 3HC/COT ratio measured in the saliva of smokers is highly correlated with the intrinsic hepatic clearance of nicotine and, therefore, may be a useful non-invasive mar...

The circadian variation of the toxicity and nociceptive actIvity of aminophylline as an important methylxanthine was studied in mice. The animals were housed under controlled light-dark cycles for at least 2 weeks. Acute toxicity was determined by LD50. Hot-plate test was used for determination of thermal pain threshold. Doses of 200, 250, 280 and 340 mg/kg of aminophylline were injected i...

Circadian variation has been demonstrated in several clinical parameters used to assess disease activity in rheumatoid arthritis, but circadian variation in modern laboratory assessments has not been studied in depth. We therefore made 2-hourly measurements of plasma viscosity, C-reactive protein, total serum sulphydryl, and serum histidine on samples obtained over a 24-hour period from 6 patie...