Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator effects improving symptoms in patients with acute and chronic congestive heart failure, stable coronary artery disease, acute coronary syndromes, or arterial hypertension. The mechanisms underlying vasodilation inc...

Organic nitrates have been recognized by physicians as potent vasodilators and effective therapy for angina pectoris for over 100 years."2 Despite the advent of beta-blockers and calcium channel antagonists in the 1960s the organic nitrates remain important antianginal agents and are well-established as the drugs of choice in acute angina. Recently interest in nitrate therapy has increased as a...

AIMS Brief episode(s) of ischaemia may increase cardiac tolerance to a subsequent major ischaemic insult ('preconditioning'). Nitrates can pharmacologically mimic ischaemic preconditioning in animals. In this study, we investigated whether antecedent nitrate therapy affords protection toward acute ischaemic events using data from the Global Registry of Acute Coronary Events. METHODS AND RESUL...

This study investigated the effects of arsenic on the in vitro activities of the enzymes (nitrate reductase and nitrite reductase) involved in nitrate metabolism in the roots, rhizomes, and fronds of four-month old Pteris vittata (arsenic - hyperaccumulator) and Pteris ensiformis (non-arsenic-hyperaccumulator) plants. The arsenic treatments (0, 150, and 300 microM as sodium arsenate) in hydropo...

Organic nitrates have been recognized by physicians as potent vasodilators and effective therapy for angina pectoris for over 100 years."2 Despite the advent of beta-blockers and calcium channel antagonists in the 1960s the organic nitrates remain important antianginal agents and are well-established as the drugs of choice in acute angina. Recently interest in nitrate therapy has increased as a...

Received: 17, March, 2015 Final Accepted: 17, April, 2015 Published Online: 25, April, 2015 This study examined the effect of 25.0 and 50.0 μM arsenic (As) on nitrate uptake in Chlorella vulgaris when grown under different nitrogen regime. The changes in nitrate uptake of test alga exposed to As under different N regimes show that the control cultures of test alga showed maximum nitrate uptake ...

The high affinity nitrate transport system in Arabidopsis thaliana involves one gene and potentially seven genes from the NRT1 and NRT2 family, respectively. Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes. NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root...

The mechanism through which nitrate reduces the activity of legume nodules is controversial. The objective of the study was to follow Medicago truncatula nodule activity after nitrate provision continuously and to identify molecular mechanisms, which down-regulate the activity of the nodules. Nodule H2 evolution started to decline after about 4 h of nitrate application. At that point in time, a...

High dietary nitrate and nitrite intake may increase the risk of gastro-intestinal cancers due to the In vivo formation of carcinogenic chemicals known as N-nitroso compounds. In this study nitrate and nitrite residues in smoked Caspian kutum, Rutilus frisii kutum and mullet, liza auratus in the local markets (considered as batch no. 1, 2 and 3) of north of Iran were determined using Spectropho...