The increase in blood flow evoked by synaptic activity is essential for normal brain function and underlies functional brain imaging signals. Nitric oxide, a vasodilator released by NMDA receptor activation, is critical for the flow increase, but the factors linking NMDA receptor activity to nitric oxide-dependent hyperemia are poorly understood. Here, we show that tissue plasminogen activator ...

Recently, arginase is suggested to regulate nitric oxide production by competing with nitric oxide synthase for the same substrate, L-arginine, in experimental asthma. We investigated the role of arginase and its relationship to nitric oxide production after spinal cord injury. Rats were subjected to laminectomy and complete transection of their spinal cords (injury group) or laminectomy only (...

background: angiotensin converting enzyme (ace) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin ii that is a vasoconstrictor and mitogen factor. to date, the role of angiotensin ii on regulating blood flow in inflamed joints has not been studied.   methods: acute and chronic joint inflammation was induced in rabbits by intra-articul...

Leppert, P.C. and Yu, S.Y. (1994) Apoptosis of cervical cells in pregnant rats occurs in association with cervical softening. Gynecol. Obstet. Invest., 37, 150-154. Liggins, G.C. (1981) Cervical ripening as an inflammatory reaction. In Ellwood, D.A. and Anderson, A.B.M. (eds), The Cervix in Pregnancy and Labour. Churchill Livingstone, Edinburgh, UK, pp. 1-9. Purcell, T.L., Buhmischi, I., Given,...

Nitric oxide has been shown to be implicated in neural plasticity that underlies processes of learning and memory. In the honeybee, studies on the role of nitric oxide in associative olfactory learning reveal its specific function in memory formation. Inhibition of nitric oxide synthase during olfactory conditioning impairs a distinct long-term memory that is formed as a consequence of multiple...

BACKGROUND.Nitric oxide mediates and modulates pulmonary transition from fetal to postnatal life. NO is synthesized by 3 nitric oxide synthase isoforms. One key pathway of nitric oxide metabolism results in nitrotyrosine, a stable, measurable marker of nitric oxide production. OBJECTIVE. The purpose of this study was to assess, by semiquantitative immunohistochemistry, nitric oxide synthase iso...

spinal cord injury (sci) as a destructive crash result in neurons degeneration. the sci lead to the onset of biochemical and molecular cascades such as inflammation that in turn has a key role in neurodegeneration development. the previous studies demonstrated the role of tnf-α and inos genes in intensifying the process after sci. as a consequence, these genes overexpression intensify the infla...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inducible nitric oxide synthase (inos) inhibitor on spatial memory, in both anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials...