In the present study the effects of both CCK receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. M orphine induced dose-dependent antinociception in mice. The response of morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329 and L-...

The psychopharmacology of agonists and antagonists of excitatory amino acids is in its infancy relative to the decades of intensive research associated with drugs acting on monoamine neurotransmitter systems. The prototype drug in this class, phencyclidine, and its derivative, ketamine, block the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors with competing with glutamate and witho...

The topographic ordering of retinal connections in the rat superior colliculus emerges during early postnatal life from an initially diffuse projection. Disruption of N-methyl-D-aspartate (NMDA) receptor activity in the superior colliculus during this period interferes with map remodeling. In rats chronically treated with NMDA receptor antagonists during the first two postnatal weeks, aberrant ...

MacLean, Jason N., Kristine C. Cowley, and Brian J. Schmidt. spinal cats reverses perturbations of the locomotor pattern NMDA receptor-mediated oscillatory activity in the neonatal rat produced by 5-HT agonists (Barbeau and Rossignol 1990), spinal cord is serotonin dependent. J. Neurophysiol. 79: 2804– it remains to be shown whether endogenous 5-HT receptor 2808, 1998. The effect of serotonin (...

A series of novel tricyclic pyrido-phthalazine-dione derivatives was tested for antagonistic effects at the strychnine-insensitive modulatory site of the N-methyl-D-aspartate (NMDA) receptor (glycineB). All compounds displaced [3H]MDL-105,519 binding to rat cortical membranes with IC50 values of between 90 nM and 3.6 microM. In patch-clamp experiments, steady-state inward current responses of c...

It is no longer tenable to attribute all the antipsychotic action of antipsychotic drugs to dopamine (DA) D2 receptor blockade and subsequent development of depolarization inactivation of the mesolimbic or mesocortical DA neurons. The chief evidence for this position is that clozapine (CLOZ) does not differ from typical antipsychotic drugs in these regards but is more effective than typical neu...

NMDA receptors have received much attention over the last few decades, due to their role in many types of neural plasticity on the one hand, and their involvement in excitotoxicity on the other hand. There is great interest in developing clinically relevant NMDA receptor antagonists that would block excitotoxic NMDA receptor activation, without interfering with NMDA receptor function needed for...

In the neuromuscular junction of the crayfish, the excitatory neurotransmitter is glutamate. There are two types of glutamate receptors, N-methyl-D-aspartate (NMDA) and non-NMDA receptors, both of which have been demonstrated to be present in the opener muscle and deep abdominal extensor muscle. The crayfish fast extensor muscle, however, is an understudied preparation whose receptor types are ...