Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats....

Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly generalizable as being independent of chemical/physical agent, biological model, and endpoint measured. This under-recognized and -appreciated concept has the potential to profoundly change toxicology and its r...

In this paper, the quantitative structure-activity relationship predictive models (QSAR) are presented: prediction model for some of main components cannabis sativa, acute toxicity LD50 (n=45, r2=0.917, q2=0.902), chronic LOAEL (n=35, r2=0.911, q2=0.868), NOAEL(n=22, r2=0.964, q2=0.937), LOEL (n=26, q2=0.863) and NOEL (n=25, r2=0.867, q2=0.802), in addition to carcinogenicity mutagenicity effec...

UNLABELLED One mechanism of resistance to trastuzumab in human epidermal growth factor receptor-2 (HER2)-positive breast cancer (BC) is increased epidermal growth factor receptor (EGFR) expression. We have developed (111)In-labeled bispecific radioimmunoconjugates (bsRICs) that bind HER2 and EGFR on BC cells by linking trastuzumab Fab fragments through a polyethylene glycol (PEG24) spacer to ep...

The quinoxaline derivatives are an important class of heterocyclic compounds, obtained from chemical azote replacement of carbone atom. Fusion of quinoxaline production is relatively easy as they are obviously synthesized by the fusion of two aromatic rings, benzene and pyrazine. The new quinoxalinique derivative, 6-nitro-2 (1H)-quinoxalinone (NQX), has been synthesized in our laboratory. Howev...

Recently collected dietary exposure data on mineral oil saturated (MOSH) and aromatic (MOAH) hydrocarbons were used to evaluate the risks associated with through food for Belgian population. For MOSH, no observed adverse effect level (NOAEL) value of 19 mg kg−1 bw day−1 based hepatic inflammation-associated granulomas found in a 90-day oral study F-344 rats was as point departure (PoD). Due exi...

The erroneous assumption that herbal products is generally safe for consumption, a major factor leading to the increased of herb-induced liver injury (HILI). Even though Laurus nobilis or laurel commonly used spice, safety aspect its consumption under-studied. To bridge this gap knowledge, mutagenicity, acute toxicity, and subacute toxicity LAURESH®, which standardized leaf extract were evaluat...