BACKGROUND Melanoma incidence and mortality rates have increased over the past 30 years in the Caucasian population. In Brazil, data on non-capital cities are scarce, making epidemiological stu dies necessary. OBJECTIVES To evaluate the incidence of and classify cutaneous melanomas in Blumenau from 1980 to 2009. METHOD Data from 1002 histopathological examinations of individuals from Blumen...

BACKGROUND The incidence and mortality of malignant melanoma have been rising during the past decades, the latter being due to the high invasion capacity and the metastatic potential of melanoma cells to distant organs. OBJECTIVE We investigated the distribution pattern of melanoma metastases taking into account different clinicopathological subtypes of melanoma. METHODS We studied 310 stag...

A 39-year-old man noted a pigmented lesion on his back that had been growing for ;1 year. A punch biopsy demonstrated malignant melanoma, nodular type. He was also found to have a white blood cell count of 45.8 3 10/mL and palpable axillary, cervical, and inguinal lymph nodes. The blood was sent for flow cytometry and demonstrated a population of small CD19 B cells that were l light chain restr...

Nodular basal cell carcinoma, especially when pigmented, can be in differential diagnosis with nodular melanomas, clinically and dermoscopically. Reflectance confocal microscopy is a relatively new imaging technique that permits to evaluate in vivo skin tumors with a nearly histological resolution. Here, we present four cases of challenging nodular lesions where confocal microscopy was able to ...

Abstract Purpose Nodular melanoma (NM) is associated with worse disease outcome when compared to superficial spreading (SSM). We aimed perform a single-center analysis of prognostic factors in patients NM and compare the data SSM patients. Methods studied 228 NN 396 SSM. Patients situ melanomas or stage IV at diagnosis were not included study. Data analyzed using Mann–Whitney test, Chi-square K...

Malignant melanomas (MM) of the oral cavity are extremely rare, accounting for 0.2% to 8.0% of all malignant melanomas. Malignant melanomas is more frequently seen at the level of the hard palate and gingiva. Early diagnosis and treatment are important for reducing morbidity. Malignant melanoma cells stain positively with antibodies to human melanoma black 45, S-100 protein, and vimentin; there...

Isolated pleural metastasis with pleural effusion is a rare occurrence in malignant melanoma. We report an unusual case of a patient with chronic lymphocytic leukemia (CLL) and recurrent pleural effusions. The pleural fluid cytology and immunohistochemistry profile were consistent with the diagnosis of CLL. However, chemotherapy with pentostatin, cyclophosphamide, and rituximab did not result i...