The authors found that the neural cell adhesion molecule (NCAM) is hyposialylated in hereditary inclusion body myopathy (HIBM) muscle, as suggested by its decreased molecular weight by Western blot. This abnormality represented the only pathologic feature differentiating HIBM due to GNE mutations from other myopathies with similar clinical and pathologic characteristics. If further confirmed in...

IntroductIon Over the last decade the fields of knowledge management and organizational learning have developed rapidly, showing increasing diversity and specialization in the academic literature. Ikujiro Nonaka has played a leading role in setting standards and earning academic legitimacy for the emergent field of " organizational knowledge management " (Easterby-Smith & Lyles, 2003). In the p...

Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy is caused by mutations in GNE, a key enzyme in sialic acid biosynthesis. Here, we reported a case of GNE that presented with atypical mild clinical feature and slow progression. A 48-year-old female had a complaint of left foot drop since the age of 46 years. Electromyography (EMG) and muscle biopsy from left tibia...

This paper discusses the knowledge management issues involved in developing an integrated, support system for the visa approval process at the US Immigration and Naturalization Service agency. This research combined competitive intelligence analysis methods with an understanding of human knowledge as dynamic, socially constructed and situated in context, to determine appropriate roles for IT an...

Transaction cost economic theory (Williamson 1975; Grossman and Hart 1986; Klein, Crawford and Alchain 1978) supports expectations that market forces will increase with the proliferation of information technology since coordination costs between firms will decrease (Malone, Yates and Benjamin 1987). Despite the ability of rr to reduce coordination costs, there has been a trend to fewer but clos...

Management consulting firms are typical examples of knowledge-intensive organisations in which the consultants’ knowledge, in particular tacit knowledge, is critical to the success of the firms. The firm’s success depends on its continuous effort to retain the consultant’s tacit knowledge. This chapter will explore the conversion processes of consultants’ tacit knowledge to the organisational e...

In most companies two factors play a crucial role: managing the knowledge that is necessary for doing business and managing the hardware and software infrastructure that supports the business processes. Usually, business processes and infrastructure are not optimally aligned. We investigate how principles from knowledge management can be applied to enable the creation, consolidation, conservati...

Creation of knowledge and the management thereof is of great importance if industry players are to survive in competitive environments. The Socialisation-ExternalisationCombination-Internalisation (SECI) model of Nonaka is one theoretical model of how tacit and explicit knowledge is processed within organisations. Research on knowledge creation in Construction Management (CM) has made reference...

CSCL is based on the idea that computer applications can scaffold and implement advanced socio-cognitive processes for knowledge sharing and knowledge building. But do we really understand these processes that are supposed to be implemented? This paper will focus on the "epistemological infrastructure" of CSCL. We will analyze three models of innovative knowledge communities in order to better ...

The final goal of Information Retrieval (IR) is knowledge production. However, it has been argued that knowledge production is not an individual effort but a collaborative effort. Collaboration in information retrieval is geared towards knowledge sharing and creation of new knowledge by users. This paper discusses Collaborative Information Retrieval (CIR) and how it culminates to knowledge crea...