The objective of this investigation was to identify the lineages of MRSA and MSSA with reduced susceptibility to chlorhexidine in Kuwaiti hospitals. 121 clinical MRSA and 56 MSSA isolates were included in this study. Antimicrobial susceptibility testing was performed for a selection of agents including chlorhexidine and resistance genes were amplified and sequenced. PFGE, spa typing, and MLST w...

OBJECTIVES We report the synthesis, antibacterial activity and toxicity of 24 bis-indolic derivatives obtained during the development of new ways of synthesis of marine bis-indole alkaloids from the spongotine, topsentin and hamacanthin classes. METHODS Innovative ways of synthesis and further structural optimizations led to bis-indoles presenting either the 1-(1H-indol-3'-yl)-1,2-diaminoetha...

The ongoing conflict between viruses and their hosts can drive the co-evolution between host immune genes and viral suppressors of immunity. It has been suggested that an evolutionary 'arms race' may occur between rapidly evolving components of the antiviral RNAi pathway of Drosophila and viral genes that antagonize it. We have recently shown that viral protein 1 (VP1) of Drosophila melanogaste...

Martin T Dove1, Mark Calleja1, Jon Wakelin1, Kostya Trachenko1, Guillaume Ferlat1, Peter Murray-Rust2, Nora H de Leeuw3, Zhimei Du3, G David Price4, Paul B Wilson4, John P Brodholt4, Maria Alfredsson4, Arnaud Marmier5, Richard P Tyer6, Lisa J Blanshard6, Robert J Allan6, Kerstin Kleese van Dam6, Ilian T Todorov6, William Smith6, Vassil N Alexandrov7, Gareth J Lewis7, Ashish Thandavan7, S Mehmoo...

J. Barreiros, E. Costa Centre of Informatics and Systems of University of Coimbra, Polo II, Pinhal de Marrocos, 3030 Coimbra, Portugal [email protected], [email protected] J. Fonseca Dep. Electronic and Telecomunications of University of Aveiro, Campus Santiago, 3800 Aveiro, Portugal [email protected] F.Coutinho Superior Institute of Engineering of Coimbra, Quinta da Nora, 3030 Coimbra, Portugal fern...

WEI SHI,1 NORA HEISTERKAMP,2 JOHN GROFFEN,2 JINGSONG ZHAO,3 DAVID WARBURTON,1,3 AND VESA KAARTINEN1 1Developmental Biology Program and 2Section of Molecular Carcinogenesis, Childrens Hospital Los Angeles and University of Southern California School of Medicine, Los Angeles 90027; and 3Center for Craniofacial Molecular Biology, University of Southern California School of Medicine and Dentistry, ...

Liver Histology in Hepatitis B and C Co-Infection on Hemodialysis Patients N. Nora Franceschini L.F. Luis Felipe Goncalves C.A. Carlos Alberto Prompt S.G.S. Sergio G.S. Barros C.T.S. Carlos T.S. Cerski C.A.R. Cesar A.R. Costa Division of Nephrology and Division of Gastroenterology, Department of Medicine and Department of Pathology, School of Medicine of Universidade Federal do Rio Grande do Su...

Luca Arcaini, Mario Lazzarino, Nora Colombo, Sara Burcheri, Emanuela Boveri, Marco Paulli, Enrica Morra, Marcello Gambacorta, Sergio Cortelazzo, Alessandra Tucci, Marco Ungari, Achille Ambrosetti, Fabio Menestrina, Lorella Orsucci, Domenico Novero, Alessandro Pulsoni, Maurizio Frezzato, Gianluca Gaidano, Daniele Vallisa, Viviana Minardi, Claudio Tripodo, Vincenzo Callea, Luca Baldini, Francesco...

The use of radiopharmaceuticals for the diagnosis of infection is increasing due to their ability to distinguish between septic and aseptic inflammation. The aim of this study was to analyze the intracellular accumulation of technetium-99m-ciprofloxacin in strains of Staphylococcus aureus and Pseudomonas aeruginosa harboring an overexpression of NorA and MexAB-OprM, respectively.

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