نتایج جستجو برای: nortriptyline hydrochloride
تعداد نتایج: 44787 فیلتر نتایج به سال:
Studies were conducted to evaluate the potential mechanism-based inactivation of recombinant and human liver microsomal CYP2C8 by clinically used drugs. Several tricyclic antidepressants, calcium channel blockers, monoamine oxidase inhibitors, and various other known CYP3A4 inhibitors exhibited greater inhibition of CYP2C8 (paclitaxel 6alpha-hydroxylation) following preincubation, consistent wi...
doi: 10.3969/j.issn.1002-0829.2012.06.009 Division of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA *Correspondence: [email protected] Psychiatric studies often collect longitudinal data to characterize the natural history of disease in a cohort or to evaluate the effect of behavioral or pharmaceutical interventions. For example, in a recent partially ra...
We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B. This case suggests the clinical usefulness of pharmacogenetic testing in individual...
abstract: spectrophotometric studies were successfully used in quantitative analysis of amitriptyline hydrochloride (ath) two new methods using spectrophotometry are described for the determination of (ath) with potassium bromate as the oxidizing agent and acid dyes, methyl orange and indigo carmine. both spectrophotometric methods are based on the oxidation of mentioned drugs by a known excess...
Background: Nortriptyline and venlafaxine are commonly used antidepressants for treatment of depression in older patients. Both drugs are metabolized by the polymorphic cytochrome P450-2D6 (CYP2D6) enzyme and guidelines for dose adaptations based on the CYP2D6 genotype have been developed. The CYP2D6 Screening Among Elderly (CYSCE) trial is designed to address the potential health and economic ...
In recent years there has been increasing focus on the role of the drug transporter P-glycoprotein (P-gp) with regard to drug penetration into the brain. Being located at the blood-brain barrier (BBB), P-gp actively pumps drugs out of the brain, and studies in P-gp knockout mice have revealed that P-gp can have a profound effect on the ability of some drugs to enter the brain. Important example...
OBJECTIVE The aim of this study was to evaluate the efficacy of a therapeutic pathway for vestibular migraine (VM) and complex dizziness of undetermined etiology (CDUE) with caffeine cessation and pharmacotherapy. STUDY DESIGN This study is a retrospective chart review. INTERVENTION(S) Patients were recommended to stop intake of caffeine and other putative migraine-triggering agents. Pharma...
BACKGROUND Migraine is a prevalent neurological disorder. Although prevention is the mainstream treatment, some patients are refractory to standard therapies. AIM To evaluate the use of quetiapine (QTP) in the preventive treatment of refractory migraine, defined as previous unresponsiveness to the combination atenolol + nortriptyline + flunarizine. METHOD Thirty-four consecutive patients (3...
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