Abstract We conducted a systematic review of human trials examining the effects dietary phytochemicals on Nrf2 activation. In accordance with PRISMA guidelines, Medline, Embase and CAB abstracts were searched for articles from inception until March 2020. Studies in adult humans that measured activation (gene or protein expression changes) following ingestion phytochemical, either alone combinat...

Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve platforms for autophagosome formation and nuclear factor erythroid 2-related 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination with impaired bulk selective ...

Human aging is a multifactorial process. The most prominent effects of aging include visual impairments, particularly age‑related cataracts (ARC). Several studies have reported that oxidative stress and failure of the antioxidant system are the major factors contributing to lens oxidation. The present study focused on the nuclear factor erythroid 2‑related factor 2 (Nrf2)/kelch‑like ECH‑associa...