Peter D. Williamson died in his home in Lyme, New Hampshire on June 4th, 2008 after a courageous year-long battle with lung cancer. With his passing the neurology community lost a compassionate advocate, clinician, researcher and fundraiser in the field of epilepsy and epilepsy surgery. He is survived by his wife Susan, their four children, and six grandchildren. Peter D. Williamson was born in...

introduction: the aim of present study was to estimate effective dose from most common procedures performed in nuclear medicine departments of golestan province. methods: data of nuclear medicine procedures performed in 2 nuclear medicine departments in golestan province were collected during 4 years. effective dose, collective effective dose and effective dose per examination were calculated u...

BACKGROUND High-field 3.0 T MR scanners provide an improved signal-to-noise ratio which can be translated in higher image resolution, possibly allowing critical detection of subtle epileptogenic lesions missed on standard-field 1.0-1.5 T MRIs. In this study, the authors explore the potential value of re-imaging at 3.0 T patients with refractory partial epilepsy and negative 1.5 T MRI. METHODS...

While several newer AEDs have study data that support monotherapy usage, most possess FDA indications for adjunctive treatment of partial onset seizures, leading to their initial (and often persistent) clinical use as adjunctive polytherapy for patients with refractory epilepsy. This review considers a practical approach to the appropriate role for polytherapy in epilepsy, presents the evidence...

BACKGROUND Status epilepticus (SE) is a common neurological emergency. In around 10 percent, the etiology of SE is not clear, i.e. cryptogenic SE. AIM To describe six young adult patients with de novo cryptogenic multifocal febrile SE with poor outcome. METHODS Retrospective chart review. RESULTS We describe six patients who presented with de novo SE. All were young adults with an unremar...

Neurosteroids such as allopregnanolone are positive allosteric modulators of GABAA receptors with powerful antiseizure activity in diverse animal models. Neurosteroids may be endogenous regulators of seizure susceptibility, for example, in catamenial epilepsy. Clinical trials with the synthetic neurosteroid analog ganaxolone in the treatment of refractory partial seizures and infantile spasms h...

objective in the majority of patients with intractable epilepsy, seizures can be well controlled with appropriate medication. however, current estimates indicate that some of patients with epilepsy are refractory to all forms of medical therapy. the surgical treatment of intractable epilepsy in children has  evolved with advances in technical innovations. these medically intractable patients ar...

OBJECTIVES Although epileptic seizures are an infrequent feature of acute attacks of the neuropsychiatric porphyrias, there are no significant reports of porphyria in chronic epilepsy. This paper attempts to redress the balance. METHODS Three case reports, including detailed laboratory and molecular diagnostics. RESULTS Two patients with variegate porphyria and one with acute intermittent p...

Trends in alternative medicine use by American health care consumers are rising substantially. Extensive literature exists reporting on the effectiveness of neurofeedback in the treatment of autism, closed head injury, insomnia, migraine, depression, attention deficit hyperactivity disorder, epilepsy, and posttraumatic stress disorder. We speculated that neurofeedback might serve as a therapeut...

7. M A C L E O D , C M . ; D E K A B A N , A . S . & H U N T , E . — M e m o r y i m p a i r m e n t i n e p i l e p t i c p a t i e n t s : s e l e c t i v e e f f e c t s of p h é n o b a r b i t a l c o n c e n t r a t i o n . S c i e n c e 202:1102, 1978. 8. M A T T S O N , R . H . & C R A M E R , J . A . — P h é n o b a r b i t a l : t o x i c i t y . I n D . M . W o o d b u r y , J . K . ...