Optical spectroscopy was used to evaluate the transformation of nuclear morphology associated with intraepithelial neoplasia in an animal model of carcinogenesis. In this pilot study, we have assessed the capability of angle-resolved low-coherence interferometry (a/LCI) to monitor in situ the neoplastic progression of hamster trachea epithelial tissue. By using the depth resolution made possibl...

BACKGROUND Prediction of radiation response before the completion of the radiotherapy schedule is challenging. Information about radiation response could help oncologist to choose the appropriate combination and sequence of therapies in the multidisciplinary management of cancer. METHODS The study involved 26 patients with squamous cell cancers of the head and neck region who received radioth...

Objective: The differentiation of atypical complex type endometrial hyperplasia (ACEH) and low grade endometrial carcinoma (EC) may be problematic in endometrial biopsy materials. Desmoplasia and stromal invasion are diagnostic for EC but they are not always demonstrated in endometrial biopsies. In this study, we investigated the contribution of nuclear morphometry to distinction of ACEH and lo...

In 2 studies, a method of linear morphometry was applied to regulatory developmental neurotoxicity studies in the rat. The first study involved the development of the brain during postnatal days (PNDs) 7-63, and the second involved the effects of 8 mg/kg i.p. trimethyltin chloride (TMT) to rats at PND 8, with morphometry performed at PNDs 12 and 24. The results of the TMT linear morphometry wer...

We investigated the reproducibility of a semiautomated method (computerized with manual intervention) for nerve morphometry (counting and measuring myelinated fibers) between three observers with different levels of expertise and experience with the method. Comparisons between automatic (fully computerized) and semiautomated morphometric methods performed by the same computer software using the...

Following denervation, skeletal muscle undergoes rapid loss in both mass and contractile force, with an accompanying series of changes in structure, biochemistry and physiology. Morphologic features of the long-term denervated muscle suggest that the original fibers are lost and those seen are the results of repeated cycles of cell death and regeneration. Markers of myogenic events in adult mus...

The similarity in enzyme profile between microsomal preparations and nuclear envelopes has been shown for a range of enzymes in adult liver of various species (Franke, 1974; Kasper, 1974). The degree to which the enzymes in these two membrane systems can be induced is, however, variable. In rat liver, phenobarbital produced a two to three times increase in NADPH-cytochrome c reductase (EC 1.6.2...

Following denervation, skeletal muscle undergoes rapid loss in both mass and contractile force, with an accompanying series of changes in structure, biochemistry and physiology. Morphologic features of the long-term denervated muscle suggest that the original fibers are lost and those seen are the results of repeated cycles of cell death and regeneration. Markers of myogenic events in adult mus...

Introduction: Voxel based morphometry is a type of statistical parametric mapping that can be used to investigate the effect of diseases such as epilepsy, Alzheimer's disease and Parkinson's disease or other agent such as skills on brain structure (white matter, gray matter and cerebrospinal fluid). The aim of this study is evaluate the effectiveness of this method in detection of differen...