Objectives Failure to publish findings from research is a significant area of research waste. It has previously been suggested that potentially over 50% of studies funded are never published. This study aimed to investigate what percentage of NIHR HTA programme funded projects have published their final reports in the programme’s journal Health Technology Assessment, (the monograph series); and...

BACKGROUND Decision-analytic modelling (DAM) has become a widespread method in health technology assessments (HTA), but the extent to which modelling is used differs among international HTA institutions. In Germany, the use of DAM is optional within HTAs of the German Institute of Medical Documentation and Information (DIMDI). Our study examines the use of DAM in DIMDI HTA reports and its effec...

Employment or Leadership: D. Mant, Oxford University. Consultant or Advisory Role: None declared. Stock Ownership: None declared. Honoraria: None declared. Research Funding: Funding from the U.K. National Institute for Health Research Health Technology Assessment (NIHR HTA) program (project no. 99/10/99) to the Nuffield Department of Primary Care Health Sciences, University of Oxford. Expert Te...

UNLABELLED Chitosan is a biocompatible polysaccharide composed of glucosamine and N-acetylglucosamine. The polymer has a unique behavior of fluctuating between soluble chains at pH 6 and insoluble microparticles at pH 7. The purpose of this study was to test the hypothesis that chitosan structure, solubility state, and serum influence the rate of cell uptake. Chitosans with 80% and 95% degree o...

Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibi...

A simple and convenient method for the construction of CdSe/ZnS-labeled polysaccharides as bioprobes were developed, which are highly biocompatible and photostable, and have been proven to be suitable for live cell imaging.

background: this study intends to determine the diagnostic and prognostic roles of hypermethylation of serum rassf1a and protocadherin-10 promoters in females with breast cancer. methods: this study enrolled 80 breast cancer patients and 80 apparently normal healthy controls. the promoter methylation status of serum rassf1a and pcdh10 genes was investigated using methylation specific pcr. resul...

In the title compound, [Co(C(5)H(9)O(2))(2)(C(12)H(8)N(2))(H(2)O)], the Co(II) atom is coordinated in a distorted octahedral environment by three carboxyl O atoms of two trimethyl-acetate ligands, one aqua O atom and two N atoms from 1,10-phen-anthroline. The crystal structure is stabilized by O-H⋯O hydrogen bonds and π-π stacking inter-actions [inter-planar distance between inter-digitating 1,...

-A simple, efficient, and general method has been developed for the chemoselective acetalization of aldehydes with 1,3-propanediol, 1,2-ethanediol and trimethyl orthoformate in the presence of solid lithium perchlorate under solvent-free conditions. Both cyclic and acyclic acetals of aldehydes were obtained under environmentally benign conditions in good to excellent yields.