Stevenson, Dobriner, and Rhoads (5) reported that p-dimethylaminoazobenzene when fed to rats is decomposed and metabolized to several simpler compounds. One of these split products, N,N-dimethylp-phenylenediamine, has been found by us ( i ) to be toxic to the glandular epithelium of the rat liver at concentrations of o.oooI M, while equivalent effects on the ductal epithelium were produced only...

Azalactone 1 can be synthesized via treatment of 4chlorobenzoyl glycine with p-anisaldehyde in the presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles, for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4thiadiazole can be investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydroch...

A new series of transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from the Schiff base ligand derived from 4-aminoantipyrine, furfural and o-phenylenediamine. The structural features were derived from their elemental analyses, infrared, UV-visible spectroscopy, NMR spectroscopy, thermal gravimetric analyses, ESR spectral analyses and conductivity measureme...

The glucose biosensors were prepared by the electropolymerization of the non-conductive polymer, Poly(o-phenylenediamine), onto a planar screen-printed electrode. A fabrication procedure was performed to decrease the waste of expensive enzyme. The amperometric glucose response was measured by the potensiostating of the prepared glucose biosensors at a potential of 0.3 V with ferrocene as mediat...

We report a suitable quinoxaline synthesis using molybdophosphovanadates supported on commercial alumina cylinders as catalysts. These catalysts were prepared by incipient wetness impregnation. The catalytic test was performed under different reaction conditions in order to know the performance of the synthesized catalysts. The method shows high yields of quinoxaline derivatives under heterogen...

Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV,...

Given the widespread interest in antioxidant nutrients, we have developed a new procedure that will permit the automated determination of plasma ascorbic acid (AA) concentration with a Roche Fara centrifugal analyzer. After the deproteinization of plasma with metaphosphoric acid, AA is oxidized to dehydroascorbic acid by AA oxidase. The product is coupled to o-phenylenediamine to produce a chro...

A halogenmethylsulfonyl moiety is incorporated in numerous active herbicides and fungicides. The synthesis of tribromomethyl phenyl sulfone derivatives as novel potential pesticides is reported. The title sulfone was obtained by following three different synthetic routes, starting from 4-chlorothiophenol or 4-halogenphenyl methyl sulfone. Products of its subsequent nitration were subjected to t...

A series of (benzamidostyryl)benzimidazole derivatives were synthesized by hydrolyzing 2-phenyl-4-(substituted)benzylidene-5-oxazolones, the azlactone precursors in an acidic medium and treating the product with substituted o-phenylenediamine (OPDA) in situ. The structures of the synthesized compounds were confirmed by spectral and elemental analyses. All synthesized compounds were screened for...