A 31 year-old female with Trisomy 21, uncorrected complete atrioventricular septal defect (AVSD) and consequent Eisenmenger syndrome presented to our emergency department with dyspnea, hypoxia, and worsening cyanosis. She was found to be hemodynamically stable with a heart rate of 70 bpm and blood pressure of 100/60. There was no pulsusparadoxus. She was notably cyanotic, platypneic, and hypoxi...

If the diffusive component of O2 transport in muscle is important in determining exercise capacity, an increased capillary-to-tissue PO2 difference should enhance gas exchange from blood to skeletal muscle during exercise. Thus a rightward shift in the O2 dissociation curve should theoretically increase O2 extraction and improve maximal O2 uptake (VO2 max). To test this hypothesis, we used the ...

We hypothesized that impaired O2 transport plays a role in limiting exercise in patients with chronic renal failure (CRF). Six CRF patients (25 +/- 6 yr) and six controls (24 +/- 6 yr) were examined twice during incremental single-leg isolated quadriceps exercise. Leg O2 delivery (QO2(leg)) and leg O2 uptake (VO2(leg)) were obtained when subjects breathed gas of three inspired O2 fractions (FI(...

A micro-Fick method has been developed to measure the O2 consumption of different regions of an organ. The method was tested in isolated dog gracilis muscle and consisted of microspectrophotometric determination of arterial and venous O2 saturation in quick frozen tissue to determine O2 extraction and flow measured with 85Sr-labeled microspheres, with O2 consumption calculated from the product....

The difference was studied between O2 transport in lifelong Tibetan adolescents and in newcomer Han adolescents acclimatized to high altitude. We measured minute ventilation, maximal O2 uptake, maximal cardiac output, and arterial O2 saturation during maximal exercise, using the incremental exercise technique, at altitudes of 3,417 and 4,300 m. The groups were well matched for age, height, and ...

BACKGROUND After severe muscle trauma, hypoxia due to microvascular perfusion failure is generally believed to further increase local injury and to impair healing. However, detailed analysis of hypoxia at the cellular level is missing. Therefore, in the present work, spectroscopic measurements of microvascular blood flow and O2 supply were combined with immunological detection of hypoxic cells ...

Blood respiratory, acid–base, and ionic changes in response to hyperosmotic shock were studied in vivo and in vitro in the European flounder. One primary aim was to evaluate regulatory changes in red blood cell (RBC) volume and its interrelationship with blood O2 transporting properties. An acute increase in the ambient salinity from 10 to 30 ppt caused small but significant increases in extrac...

Introduction: The traditional view that neonates are not capable of perceiving pain has been refuted and there is now no doubt those neonates feel pain. Although babies cannot express their pain as older children, but capable to show in response the pain a set of measures as observable behavioral responses. The aim of this study was to determine Effect of foot reflexology on physiologic index o...

We tested the hypothesis that maximal exercise performance in adults with cystic fibrosis is limited by arterial hypoxemia. In study 1, patients completed two maximal exercise tests, a control and a test with 400 ml of added dead space. Maximal O2 consumption was significantly lower in the added dead space study vs. control (1.04 +/- 0.15 vs. 1.20 +/- 0.11 l/min; P < 0.05), with no difference i...