In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Com...

Current cognitive-behavioral models of the etiology of obsessive-compulsive disorder (OCD) suggest that maladaptive appraisal of otherwise normal intrusive thoughts have their origins in early learning experiences. The present study investigated the relationship between adverse childhood experience and OCD symptoms and related dysfunctional beliefs in a general population using a structural equ...

OBJECTIVE This study examined implicit sequence learning in patients with obsessive-compulsive disorder (OCD) under dual-task conditions. Frontal-striatal networks support implicit learning and are implicated in the pathophysiology of OCD. Neuroimaging data suggest that during implicit learning, OCD patients use neural systems normally active during explicit learning to compensate for striatal ...

SSRI’s are an effective pharmacological treatment strategy for treating symptoms of OCD. The benefit of treating OCD using SSRI’s was discovered as an unintended beneficial side effect from the treatment of depression using SSRI’s. While not everyone who experiences OCD symptoms benefit from SSRI’s, novel treatment approaches examining the augmentation of SSRI’s have been shown to provide addit...

BACKGROUND Temper outbursts in youth with obsessive-compulsive disorder (OCD) are a common source of concern, but remain poorly understood. This study examined a set of hypotheses related to: (a) the prevalence of temper outbursts in paediatric OCD, (b) the associations of temper outbursts with OCD severity and depressive symptoms; and (c) the influence of temper outbursts on treatment response...

BACKGROUND There is evidence to suggest that obsessive-compulsive disorder (OCD) is associated with structural abnormalities in cortico-striato-thalamic circuits, yet the extent of white matter abnormalities is not well established. In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD. METHODS Patie...

BACKGROUND Impaired language processing is one of the most replicated findings in functional brain studies of schizophrenia (SCH). This is demonstrated by reduced activations in left prefrontal language areas (i.e., BA44/45, the inferior frontal gyrus, IFG) presented as decreased language lateralization. This finding was documented both in chronic as well as in first-episode SCH patients, argui...

Memory deficits in patients with obsessive-compulsive disorder (OCD) have been frequently reported but are not sufficiently accounted for by cognitive models of OCD. The aim of the study was to identify cognitive mechanisms that might be able to explain memory deficits in OCD. We hypothesized that a self-conscious meta-cognitive style might be responsible for reduced memory performance in OCD. ...

There is constant interest in possible relations between obsessive-compulsive disorder (OCD) and eating disorders, particularly anorexia nervosa (AN). The comorbidity rate for OCD and AN is reported to be between 10% and even 40%. There is also an increased incidence of prior AN in OCD patients and high number of anorectic patients with obsessional premorbid personality. Similarities between AN...

Few medications are effective in treating obsessive-compulsive disorder (OCD). As monotherapy, only potent serotonin (5-HT) reuptake inhibitors (SRIs) consistently exert an intrinsic therapeutic action in OCD. Their use in OCD, however, differs from their use in depression. This paper first reviews the evidence supporting the key role of 5-HT as a pivotal neurotransmitter in the anti-OCD respon...