Neurobiological research in obsessive-compulsive disorder (OCD) consistently demonstrates an association between abnormal brain activity and symptom severity. Conversely, research addressing the corresponding neuropsychological impairments in OCD and their association with symptom severity has produced inconsistent results. This study reexamines neuropsychological performance and its associatio...

Scrupulosity is a moral/religious subtype of obsessive–compulsive disorder (OCD) that remains understudied within the extant literature. Drawing from separate lines of research suggesting that attachment insecurities underlie OCD and that God functions psychologically much like other attachment figures, we examined a purported association between attachment to God and scrupulosity. A large samp...

Obsessive Compulsive Disorder (OCD) is an anxiety disorder, characterized by repetitive unwanted obsessions and compulsions, with a prevalence of 0.5-1% to 4% in childhood and adolescence. The exact pathogenesis of OCD remains uncertain but multiple components such as hereditary/genetic, cognitive, biological, environmental and behavioral factors have been implicated. The aim of this review is ...

We report a case of a girl with a history of obsessive-compulsive disorder (OCD) subsequently exhibiting psychosis. She never attained remission since the outset. Initially she seemed to be resistant to most antipsychotics, namely, risperidone, haloperidol, paliperidone, quetiapine, and clozapine. However, she later responded remarkably better to risperidone after it was reintroduced for the se...

Obsessive-compulsive disorder (OCD) has long been associated with epilepsy The link with temporal lobe (usually refractory) epilepsy (TLE) is particularly prominent Of TLE patients, 10% to 22% of patients may have OCD, often underdiagnosed in the outpatient clinic. Data on the links include case reports, case series, and controlled studies. Three larger, controlled studies in TLE patients, usin...

OBJECTIVES To study the relation between obsessive-compulsive symptoms (OCS) and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. METHODS We undertook a prospective study of 113 consecutively hospitalized patients with recent-onset schizophrenia or related disorders diagnosed according to DSM-IV criteria. We compared 3 subgroups: one without c...

OBJECTIVE Obsession and compulsions in anorexia nervosa (AN) patients are often confused with the preoccupations and rituals that are characteristic of obsessive-compulsive disorder (OCD). We examined the type and frequency of characteristic OCD obsessions and compulsions in a large sample of AN patients. METHOD In personal interviews with 324 AN patients, we assessed lifetime histories of ea...

BACKGROUND The aim of this study was to determine whether dysfunctional beliefs might predict treatment-resistance and to examine the relationship between fractional anisotropy (FA) in diffusion tensor imaging (DTI) and cognitive biases for optimal treatment choice. MATERIAL/METHODS We recruited 11 non-resistant obsessive-compulsive disorder (OCD) patients, 11 resistant OCD patients, and 11 h...

Although results from neuropsychological and neuroimaging studies have postulated the involvement of the frontal lobe and the subcortical brain regions in the pathophysiology of obsessive-compulsive disorder (OCD), neuroimaging studies have provided little evidence that cognitive abnormalities in patients with OCD are related to dysfunctions in these areas. This study was designed to determine ...

Clinical and neurobiological evidence suggests that concurrent presentation of schizophrenia and obsessive-compulsive (schizo-OCD) symptoms represents a distinct clinical entity. Given that obsessive-compulsive disorder (OCD) and schizophrenia have been modeled as having different neurofunctional profiles, the overlap between them represents a heuristic challenge for cognitive and endophenotype...