Disadvantages of conventional drug delivery systems (DDS), such as systemic circulation, interaction with physiochemical factors, reduced bioavailability, and insufficient concentration at bone defect site, have underlined the importance developing efficacious local systems. Octacalcium phosphate (OCP) is presumed to be precursor biologically formed apatite, owing its similarity hydroxyapatite ...

Octacalcium phosphate (OCP) has attracted the interest of researchers looking for new biomaterials due to its excellent biocompatibility and high formability. Furthermore, it was an attraction medical combination products that ions molecule doping ability OCP, which originated distinct crystal structure. Then, as antibacterial bone substitute, Ag-substituted OCP (OCP-Ag) a candidate centerpiece...

Enamel matrix proteins, including the most abundant amelogenin and lesser amounts of enamelin, ameloblastin, and proteinases, play vital roles in controlling crystal nucleation and growth during enamel formation. The cooperative action between amelogenin and the 32-kDa enamelin is critical to regulating the growth morphology of octacalcium phosphate crystals. Using biophysical methods, we inves...

Background. This in vitro study compared the effects of mineral trioxide aggregate (MTA), calcium enriched mixture(CEM) cement, Biodentine (BD) and octacalcium phosphate (OCP) on the viability of human gingival fibroblasts (HGFs). Methods. After completion of the setting time of the materials under study, fibroblasts were placed in 24-well insert platesand 1 mg of each material was added to the...

BACKGROUND Previous studies showed that octacalcium (OCP) collagen composite (OCP/Col) can be used to repair human jaw bone defects without any associated abnormalities. The present study investigated whether OCP/Col could be applied to dental implant treatment using a dog tooth extraction socket model. METHODS The premolars of dogs were extracted; each extraction socket was extended, and tit...