The purpose of this study was to explore the potential formulating hesperetin into an ophthalmic solution with dipotassium glycyrrhizinate (DG) as a micelle nanocarrier. A DG-based encapsulating (DG-Hes) developed and its in vitro/in vivo characterizations were evaluated. optimal formulation featured DG/hesperetin (Hes) weight ratio 12:1 encapsulation efficiency 90.4 ± 1.7%; optimized DG-Hes ch...

This study aimed to investigate a food effect on the bio-availability of modified-release (MR) trimetazidine tablets in 36 healthy volunteers. Trimetazidine, an anti-ischemic drug, protects the myocardial cell from the harmful effects of ischemia. The authors investigated the effect of being under a fasting or fed state at the time of drug intake on the bioavailability of trimetazidine 35-mg MR...

SCOPE Curcumin revealed various health-beneficial properties in numerous studies. However its bioavailability is low due to its limited intestinal uptake and rapid metabolism. The aim of our project was to develop novel curcumin formulations with improved oral bioavailability and to study their safety as well as potential sex-differences. METHODS AND RESULTS In this crossover study, healthy s...

Extended Abstract Ocular drug delivery systems have the potential to improve drug bioavailability, reducing side effects and facilitating patient adherence by avoiding frequent administration, which is a major noncompliance with many chronic eye disorders as inflammatory process. Several recent studies have shown that nonsteroidal anti-inflammatory drugs are also effective in the treatment or p...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Background: Behcet syndrome is a recurrent inflammatory disorder that frequently involves the ocular system. The purpose of this study was to determine the frequency of ocular involvement in cases of Behcet's disease in Babol, north of Iran. Methods: From April 2003 to December 2009, 100 cases of behcet's disease who were admitted at the Department of Ophthalmology and Internal Medicine of Babo...

Purpose The aim of the present study was to evaluate the utility of the relatively hydrophilic Δ9-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC-Val-Val) and the amino acid (valine)-dicarboxylic acid (hemisuccinate) ester (THC-Val-HS), with respect to ocular penetration and intraocular pressure (IOP) lowering activity. THC, timolol, and pilocarpine eye drops wer...

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...