AIM To investigative whether clinical manifestations of anterior uveitis are associated with the viral load of varicella zoster virus (VZV) in the aqueous humor in patients with herpes zoster ophthalmicus (HZO) and zoster sine herpete (ZSH). METHODS After informed consent was given, an aliquot of aqueous humor was collected from patients with VZV anterior uveitis (n = 8). Genomic DNA of the h...

BACKGROUND More detailed understanding of herpes zoster (HZ) is called for in the context of an increasing observed frequency of disease, and ongoing discussions regarding potential consequences of the disease. Thus, population-based data on incidence and complications of HZ are needed. METHODS We conducted a register-based cohort study in Västra Götaland County (population 1.5 million) in Sw...

Purpose To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upp...

OBJECTIVE To determine the frequency of complications and adverse outcomes due to herpes zoster ophthalmicus before and after the introduction of oral antiviral medications in a community-based setting. METHODS We identified all Olmsted County, Minnesota, residents diagnosed with acute herpes zoster ophthalmicus from 1976 through 1998. The frequencies of complications within 6 months of disea...

Makzal Z, Edwards M. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222112 Description A girl aged 15 months presented with a 2-day history of fatigue and fever, along with a vesicular rash over her right eye and forehead (see figure 1). Swabs were sent for PCR and were positive for varicella zoster DNA, and a working diagnosis of herpes zoster ophthalmicus was made. There was no history of varicella ...

Herpes zoster ophthalmicus commonly presents with vesicular eruptions of skin along a dermatome and post herpetic neuralgia. Viral invasion into the intracranial vessel and resultant arteritis is rare complication, reported mainly in elderly, children and immunocompromised individuals. We report a young immunocompetent male who reported to us with acute right sided hemiparesis following an epis...

Intracameral injection of the normal rabbit eye with 10 50% tissue culture infectious doses of type 1 herpes simplex virus (HSV) caused uveal inflammation, biphasic elevation of intraocular pressure (IOP), and virus growth in the ocular tissues. A series of intramuscular injections of an immunosuppressive agent, cyclophosphamide (Cy), did not affect the ocular changes or the multiplication of v...

The epidemiological and clinical features of primary herpes simplex virus ocular infection in 108 patients were studied. Of these, 69 (64%) were aged 15 or over and only eight (7%) were under the age of 5. Associated upper respiratory tract infection was found in 38 (35%) patients and systemic disorders such as mild malaise, fever, and aching in 34 (31%) patients. Common symptoms were redness, ...

The monocular deprivation model of amblyopia is characterized by a reduction in cortical responses to stimulation of the deprived eye. Although the effects of monocular deprivation on the primary visual cortex have been well characterized physiologically and anatomically, the molecular mechanisms underlying ocular dominance plasticity remain unknown. Previous studies have indicated that the tra...

The development of an animal model for herpes simplex virus (HSV) reactivation is of great importance in studying HSV latency, reactivation, recurrence, and chemotherapy. Epinephrine iontophoresis to the cornea can induce HSV type 1 (HSV-1) ocular shedding from latently infected rabbits. In the present experiment, adrenergic induction of HSV-1 was enhanced by iontophoresis of 6-hydroxydopamine ...