Sebaceous gland carcinoma (SGC) of ocular adnexa is a highly malignant, multifocal in origin seen in elderly. SGCs are known to have highly virulent course of progression with more tendency to metastasize locally and systemically resulting in poor outcome. We managed a case of SGC in 55 years old with multimodality treatment consisting of surgical excision, chemotherapy for tumor bulk reduction...

PURPOSE To investigate the association between presence of orbital or ocular lesions and type and stage of leukemia and to investigate whether orbital and ocular lesions are significant in predicting leukemia prognosis. METHODS The authors evaluated 180 patients with acute childhood leukemia. Lesions associated with leukemia may be classified as specific (due to leukemic infiltration of vario...

AIMS/BACKGROUND Ten patients with metastatic tumours to the conjunctiva and the clinical aspects of this rare form of ocular metastasis are described in this study. METHOD All patients with ocular and adnexal metastatic tumours referred to an ocular oncology service were reviewed and those having conjunctival metastases were studied for the site of their primary tumour, clinical features, and...

the aim of this study was to determine the prevalence and type of ophthalmic diseases among horse populations in the suburbian riding clubs of tehran. ophthalmologic examinations were performed in 901 horses and ocular lesions were diagnosed in 40 (4.4%) animals. in the 54 eyes of these horses that had ocular defects, 103 ocular abnormalities were detected. of those horses affected, 65% showed ...

Glaucoma is a progressive neuropathy characterized by loss of vision as a result of retinal ganglion cell (RGC) death. There are no effective neuroprotectants to treat this disorder. Brain-derived neurotrophic factor (BDNF) is well known to transiently delay RGC death in ocular hypertensive eyes. The CNS-specific leucine-rich repeat protein LINGO-1 contributes to the negative regulation to some...

OBJECTIVE To evaluate outcomes of limbal allograft transplantation from living-related donors to treat partial limbal deficiency secondary to ocular chemical burns. METHODS Retrospective noncomparative case series comprising 17 patients (17 eyes) with partial limbal deficiency (≤50%) secondary to ocular alkali burns (11 eyes) or acid burns (6 eyes). Recipient eyes were treated by removing the...

Purpose Mutations in the CYP1B1 gene are the most commonly identified genetic causes of primary infantile-onset glaucoma. Despite this disease association, the role of CYP1B1 in eye development and its in vivo substrate remain unknown. In the present study, we used zebrafish to elucidate the mechanism by which cyp1b1 regulates eye development. Methods Zebrafish eye and neural crest developmen...

Introduction: Patients with bilateral weakness (BW) have many difficulties in gaze stability that interfere with their normal function. The aim of this study was to evaluate ocular motor functions in patients with BW to better understand the problem of gaze instability in these patients.   Materials and Methods: Patients were referred from the Otolaryngology Department for Vestibular Assessmen...

PURPOSE To report the clinical outcomes of deep anterior lamellar keratoplasty (DALK) when sterile gamma-irradiated acellular corneal tissues (VisionGraft) are used in combination with amniotic membrane transplantation (AMT) for intractable ocular surface diseases. METHODS The medical records of fifteen patients who had DALK with AMT were retrospectively reviewed. Indications for surgery incl...

PURPOSE To evaluate persistency with monotherapy in the treatment of glaucoma in patients new to pharmacological management. METHODS This population-based, retrospective cohort study, using managed care administrative claims data, included patients who were 20 years of age and older and who initiated monotherapy with betaxolol, brimonidine, dorzolamide, latanoprost, or timolol between May 199...