a Crect/RosaYFP mouse, in which Cre recombination leads to RosaYFP expression only in cells of ectodermal origin. In the olfactory epithelium, YFP expression (green) was detected in the majority of olfactory sensory neurons (colabeled in red) and sustentacular cells (green only). In the lamina propria, olfactory axons (red/green) and Bowman’s glands (green only) were positive for ectodermal YFP...

Spinal cord injury (SCI) has very poor clinical prospects, resulting in irreversible loss of function below the injury site. Although applied in clinical trials, olfactory ensheathing cells transplantation (OEC) derived from lamina propria (OLP) is still a controversial repair strategy. The present study explored the efficacy of OLP or respiratory lamina propria (RLP) transplantation and the op...

l-Serine is synthesized from glycolytic intermediate 3-phosphoglycerate and is an indispensable precursor for the synthesis of proteins, membrane lipids, nucleotides, and neuroactive amino acids d-serine and glycine. We have recently shown that l-serine and its interconvertible glycine act as Bergmann glia-derived trophic factors for cerebellar Purkinje cells. To investigate whether such a meta...

SCIATIC NERVE REMYELINATION AND NODAL FORMATION FOLLOWING OLFACTORY ENSHEATHING CELL TRANSPLANTATION. Mary A. Dombrowski, Masanori Sasaki, Karen L. Lankford, Hajime Tokuno, Christine Radtke, Jeffery D. Kocsis. Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, Rehabilitation Research Center, Veterans Affairs Connecti...

Introduction: Spinal cord injuries (SCI) lead to permanent irreversible functional deficits.  Poor prognosis of patients is the motivation of searching a treatment for the chronic injury.  Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results.  This study aims at evaluating the effe...