نتایج جستجو برای: oligodendrogliomas
تعداد نتایج: 585 فیلتر نتایج به سال:
Among diffuse gliomas, oligodendrogliomas show relatively better prognosis, respond well to radiotherapy and chemotherapy, and seldom progress to very aggressive tumors. To elucidate the genetic and epigenetic background for such behavior and tumor evolution during tumor relapse, we comparatively analyzed 12 pairs of primary and recurrent oligodendrogliomas with 1p/19q-codeletion. Initial treat...
BACKGROUND AND PURPOSE Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging ((1)H-MRSI) to differentiate low-grade from high-grade gliomas. MATERIALS A...
PURPOSE Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61 in glioma susceptibility and prognosis. EXPERIMENTAL DESIGN A case-control study involving 197 glioma patients and 570 controls was ...
In modern clinical neuro-oncology, histopathological diagnosis affects therapeutic decisions and prognostic estimation more than any other variable. Among high-grade gliomas, histologically classic glioblastomas and anaplastic oligodendrogliomas follow markedly different clinical courses. Unfortunately, many malignant gliomas are diagnostically challenging; these nonclassic lesions are difficul...
Abstract AIMS Oligodendrogliomas are well known to be mutated for TERTp, which is enigmatically a diagnostic criteria molecular glioblastoma by WHO2021. It generally believed that gliomas TERTp negative maintain their telomere lengths means of Alternative Lengthening Telomeres (ALT) usually reflected mutations ATRX. non-mutated ATRX unlike astrocytomas. TERT re-arrangement has also been shown a...
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