Recent studies report an increased risk of enteric infections in patients treated with proton pump inhibitors (PPIs). Polymorphonuclear neutrophils (PMNs) play a key role in host response to bacterial infection. We evaluated the effect of omeprazole and pantoprazole treatment on the PMN function. Fifteen patients were treated with omeprazole 20 mg daily and 15 patients with pantoprazole 40 mg d...

Omeprazole, a substituted benzimidazole, is known to inhibit acid secretion from parietal cells in gastric glands, and is widely utilized as a drug for peptic ulcer. To clarify the ultrastructural changes in parietal cells from long-term treatment with a therapeutic dose of omeprazole, biopsy specimens of the gastric mucosa obtained from peptic ulcer patients were morphometrically analyzed befo...

To test the hypothesis that Helicobacter pylori infection is associated with a decreased intragastric acidity during omeprazole therapy, ambulatory 24 hour dual point gastric pH recordings were performed in 18 H pylori positive and 14 H pylori negative subjects. There was a four to six week washout period between the two pH recordings made in each subject after one week courses of placebo or om...

OBJECTIVE On March 1, 2004, the state employee health plan began covering omeprazole OTC (over the counter) at a $5 copayment. Reimbursement to pharmacy providers for omeprazole OTC increased by $10.50 per claim, from $2.50 to a $13 dispensing fee. Initially, neither generic omeprazole prescription (Rx) nor brand omeprazole Rx was covered because omeprazole OTC was available in the same strengt...

Omeprazole, the acid pump inhibitor, is a new approach to the regulation of gastric acidity. Its discovery has led to new insights into the mechanism of gastric secretion, pathogenesis of certain gastrointestinal tumours and the development of new treatments for peptic ulcer. Recently this product has been marketed in Pakistan with promising results, but is yet to be evaluated in terms of long ...

conclusions: the result of our study showed that using clarithromycin, amoxicillin and omeprazole for treatment of h. pylori infection can be useful. it is concluded from lower levels of igg and caga in blood and h. pylori antigen in stool after treatment compared to the amount of these factors before therapy. considering all these data, it is obvious that there is an urgent need to found a bet...

Objective: To determine the dosing equivalents and cost effectiveness of lansoprazole versus omeprazole in maintenance therapy of gastroesophageal reflux disease (GERD). Study Design: Single-blind, randomized, crossover study. Patients and Methods: After completing a 1-week washout period, 27 outpatients (mean age, 66 years) with documented GERD were randomly assigned to receive omeprazole 20 m...

BACKGROUND Obesity is associated with a risk of gastroesophageal reflux disease. The pharmacodynamic efficacy of proton pump inhibitors has not been specifically evaluated in obese subjects. The aim of this study was to compare the antisecretory response to a single oral dose of 20 mg rabeprazole, 20 mg omeprazole and placebo in obese subjects. METHODS Gastric pH was monitored for 24 hours on...