OBJECTIVE To evaluate the characteristics of the design, analysis, and reporting of crossover trials for inclusion in a meta-analysis of treatment for primary open-angle glaucoma and to provide empirical evidence to inform the development of tools to assess the validity of the results from crossover trials and reporting guidelines. METHODS We searched MEDLINE, EMBASE, and Cochrane's CENTRAL r...

A double-blind study of pindolol eye drops 0.5% was carried out on 24 patients with primary open-angle glaucoma. Pressures were taken once weekly during three 3-week periods. In one of the periods placebo was given in both eyes, during another pindolol was given in one eye, and during another it was given in the other eye. A drop in pressure averaging 2.79% was found in eyes receiving pindolol ...

Glaucoma is a major cause of blindness worldwide. A single nucleotide polymorphism of the MTHFR gene (C677T) has been associated with susceptibility to this disease, although this is controversial in the last decade. In this study, the possible association between the MTHFR C677T polymorphism and the risk of developing primary open angle (POAG) and pseudoexfoliation glaucoma (PEXG) was investig...

Objective(s): Evaluate the effect of topical antiglaucoma drugs on tear film and determine the time taken to develop symptoms and or signs of dry eye in diagnosed open angle glaucoma patients by Schirmer's test I, Schirmer's test II, Tear film break up time. Method(s): This prospective study was carried out in 60 patients attending Ophthalmology outdoor with newly diagnosed patients of primary ...

PURPOSE The distribution of sensitivity across the visual field, as determined by automated threshold static perimetry, can be summarized in terms of visual field indices. Such indices can be weighted for the variation in threshold at each eccentricity. The aims of this study were to determine the influence of the weighting factor, the relationship between the unweighted indices derived from Pr...

Primary open angle glaucoma is an important cause of visual impairment and blindness in the United Kingdom. This paper gives a brief overview of the condition and its management. It presents evidence of the continued absence of a consensus case definition for this condition. This has resulted in considerable uncertainty about what is diagnosed and treated as primary open angle glaucoma. The imp...

Using the now well established technique ALT is a safe and effective means of lowering IOP in eyes with POAG, pigmentary glaucoma, and exfoliative glaucoma though the effect diminishes with time. Pressure reduction with ALT is seldom greater than 30% and eyes with an IOP of more than 28 mm Hg are unlikely to be controlled for any length of time without additional treatment. ALT is probably most...

We describe the prevalence and treatment of glaucoma in a Muslim Arab population in Israel. Based on the medical records of 15 122 persons, the overall prevalence of glaucoma was 3.9%. Prevalence rates of primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) were 3.0% and 0.42%, respectively. Prevalence rates of women were 135% that of men considering all types of glaucom...

Anterior megalophthalmos is a developmental anomaly of the anterior ocular segment. This is an X-linked recessive disease and manifests as bilateral enlarged corneas, open iridocorneal angle, hypoplastic iris and dislocation and opacification of an apparently small lens. We have also observed obvious vitreoretinal degeneration in our patients. What may threaten visual acuity later is an op...