We investigated the effects of beta-estradiol on the locomotor behavior of female mice in a radial maze. Data comprising the total distance traveled during each arm entry were obtained from video records of six consecutive daily recording sessions. Distributions of these data were bimodal for both ovariectomized control and beta-estradiol-treated ovariectomized subjects. Data were fit with the ...

INTRODUCTION Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is on...

objective(s): this study evaluated the effect of swimming exercise during spontaneous methamphetamine (meth) withdrawal on the anxiety, depression, obsessive-compulsive disorder (ocd) and voluntary meth consumption in meth-dependent rats.  materials and methods: male wistar rats were repeatedly administered with bi-daily doses of meth (2 mg/kg, subcutaneous) over a period of 14 days. exercised ...

Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE administration, all mice except the control group went through with 14 days of RS protocol. Stressed m...

In the present study, we have investigated the effects and interaction of CCK and GABAergic systems in the dorsal hippocampus of rats using the elevated plus-maze test of anxiety. Bilateral injection of different doses of CCK(8s) (0.01, 0.05 and 0.1 microg/rat) into the dorsal hippocampus (intra-CA1) decreased percentage of open arm time (%OAT) and open arm entries (%OAE) that are representativ...

Nicotine, an active tobacco derived alkaloid, regulates the activity of the neuronal nitric oxide synthase (nNOS) as well as the release of nitric oxide (NO) in the nervous system. Nicotinic acetylcholine receptors and nNOS are abundantly co-expressed in the hippocampal neurons and are found to alter anxiety-like behaviors in rodents. Dorsal hippocampus may be a site for modulation of anxiety. ...

Histaminergic receptors and neuronal nitric oxide synthase (nNOS) are co-expressed at high levels in the hippocampal neurons and alter anxiety-like behaviors in rodents. Since the dorsal hippocampus may be involved in modulation of anxiety-like behaviors, the aim of the present study was to assess whether the nitric oxide (NO) system in the dorsal hippocampus affects anxiety-like behaviors indu...

OBJECTIVE The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. The aim of the present study was to assess whether the histaminergic system of the NAc is involved in anxiety-related behaviors. METHODS Rats were anesthetized w...

background: testosterone level in men decreases with aging (andropause) and androgen deficiency is responsible for a variety of behavioral symptoms such as anxiety. the aim of this study was to investigate the effect of pistacia atlantica (bane) fruit extract on anxiety-like behavior in intact and gonadectomized rats. materials and methods: in this study, adult male rats were divided into two g...

The purpose of this study was to characterize the anxiolytic activity of an Aqueous extract prepared from the leaves of Mangifera indica L (AEMI) using an elevated plus maze (EPM) model in rat and staircase model in mice. In elevated plus maze (EPM) model, At dose of Mangifera indica (250mg/kg and 500mg/kg) treated group showed significant increase in the % time spent in open arm and no. of ent...