Aducanumab (brand name Aduhelm) is the first FDA-approved, pharmacologic treatment for Alzheimer’s disease (AD) but many uncertainties remain regarding both efficacy and safety. Of paramount concern are associated adverse effects including cerebral edema hemorrhage which prompted a post-approval study. Aside from safety concerns, withdrawal market may occur if it fails to demonstrate as describ...

Since columns are the most important elements of the structures, failure of one column in a critical location can cause a progressive collapse. In this respect, the repair and strengthening of columns is a very important subject to reduce the building failure and to keep the columns capacity. Twenty columns with different parameters is tested and analysis. Eleven typical confined reinforced con...

The squirrel monkey is the only primate reported to lack ocular dominance columns. Nothing anomalous about the visual capacity of squirrel monkeys has been found to explain their missing columns, leading to the suggestion that ocular dominance columns might be "an epiphenomenon, not serving any purpose" (Livingstone et al., 1995). Puzzled by the apparent lack of ocular dominance columns in squi...

In many regions of the mammalian cerebral cortex, cells that share a common receptive field property are grouped into columns. Despite intensive study, the function of the cortical column remains unknown. In the squirrel monkey, the expression of ocular dominance columns is variable, with columns present in some animals and not in others. By searching for differences between animals with and wi...

Distillation is a physical process used to separate a fluid mixture of two (binary) or more (multicomponent) substances into its component parts. In most cases, the components to be separated are miscible liquids with different volatilities and boiling points. This separation process is a thermal unit operation that utilizes the differences of vapour pressure to produce the separa‐ tion. In thi...

Recently, monolithic columns consisting of one piece of an organic polymer or silica with flow-through pores have been reported in the literature. These materials provide better stability and, more important, higher performance than conventional columns packed with particles. Although they can be prepared by various methods, monolithic columns prepared by the direct polymerization of monomers c...