Coriandrum sativum (coriander) has been documented as a traditional treatment of diabetes. On the base of this belief and as the studies about whether coriander reduces hyperglycemia in diabetic mice is little known are lacking, we decided to evaluate the effect of Aqueous Extract seed of Coriander on optic nerve in Balb/c Diabetic Mouse. In the present study, the beta cells of pancreas of 16 b...

AIM To evaluate and compare four different mathematical formulas for the early detection of morphometric optic nerve head changes in chronic open angle glaucoma. METHODS The optic nerve heads of 161 patients with perimetrically defined glaucomatous optic nerve damage and of 194 normal subjects were examined by confocal laser scanning tomography. Using four formulas of linear discriminant anal...

The visual evoked potential (VEP) recording is widely used in clinical practice to assess the severity of optic neuritis in its acute phase, and to monitor the disease course in the follow-up period. Changes in the VEP parameters closely correlate with pathological damage in the optic nerve. This protocol provides a detailed description about the rodent model of optic nerve microinjection, in w...

The detection of the optic nerve in retina images is a key element of detecting the anatomical structure of the retina. In this work we report on the fusion of two complementary optic nerve detection methods. The methods are complementary in the sense that they use different fundamental queues for locating the optic nerve. By fusing the methods through applying simple distance-based threshold, ...

Optic nerve head is part of the retina where ganglion cell axons exit the eye to form the optic nerve. Glaucomatous changes related to loss of the nerve fibers decrease the neuroretinal rim and expand the area and volume of the cup. Therefore optic nerve head evaluation is important for early diagnosis of glaucoma. This study implements the detection of the optic nerve head in retinal fundus im...

BACKGROUND/AIM Vascularisation of the distal, namely intracranial and intracanalicular parts of the optic nerve have not been explained in conventional textbooks of anatomy, while there have been explanations of proximal, that is intraorbital segment. The aim of this research was to study the pattern of arterial supply of the intracranial and intracanalicular part (the distal part) of human opt...

PURPOSE The purpose of this study was to demonstrate whether the pattern of optic nerve enhancement in magnetic resonance imaging (MRI) can help to differentiate between idiopathic optic neuritis (ON), neuromyelitis optica (NMO), and multiple sclerosis (MS) in unilateral ON. METHODS An MRI of the brain and orbits was obtained in patients with acute unilateral ON. Patients with ON were divided...

AIM To investigate the influence of acute changes in intraocular pressure on the oxygen tension in the vicinity of the optic nerve head under control conditions and after intravenous administration of 500 mg of the carbonic anhydrase inhibitor dorzolamide. METHODS Domestic pigs were used as experimental animals. Oxygen tension was measured by means of a polarographic electrode in the vitreous...

BACKGROUND Optic nerve sheath meningiomas account for only 2% of orbital lesions and 42% of optic nerve tumors. Diagnosis remains difficult because histologic confirmation carries a high risk of visual loss. Therefore, a less invasive and specific diagnostic method for differentiating optic nerve sheath meningiomas from other optic nerve lesions is needed to overcome the limitations of computed...

Optic disc pit and optic nerve coloboma are examples of congenital optic disc abnormalities. Although optic nerve coloboma can be inherited in an autosomal dominant fashion, no conclusive link has been found in the case of optic disc pit as an autosomal dominant disease. We describe two cases: a daughter with an optic disc pit complicated by maculopathy and her mother with a congenitally abnorm...