Insulinoma is the most common cause of fasting hypoglycemia resulting from autonomous insulin hypersecretion. We describe herein a unique case with paradoxical hypoglycemic episodes induced by hyperglycemia. A 55-year-old female had repeated hypoglycemic episodes after meal or during increased physical activity. Although fasting (10 hr) failed to provoke hypoglycemia, oral glucose tolerance tes...

Clinical trials have demonstrated that acute intensive insulin therapy causes a transient worsening of diabetic retinopathy in type 1 diabetes patients (1–5). The worsening results, in part, from hard exudates and macular edema — pathologies that are manifestations of blood-retinal barrier breakdown. However, continued intensive insulin therapy eventually leads to a marked reduction in the risk...

This DESG Teaching Letter was written by the DESG Executive commitee: Executive commitee: Dr. J.M. BOAVIDA, MD, Lisbon – Portugal (President); Dr. A. BROOKS, MD, Winchester – UK (Vice-President); Dr. I. HARMAN-BOEHM, MD, Sheva – Israel. (Director Educational Strategies); Ms. D. VARAKLA, Athens – Greece (Honorary Secretary); Dr. A. BALDELLI, MD, Rome – Italy (Honorary Treasurer); Dr. R. CHLUP, M...

context: over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric ph and digestive enzymes. evidence acquisition: recent reports have identified and explained the beneficial role of several struct...

BACKGROUND Add-on Lantus® to Oral Hypoglycemic Agents (ALOHA), an observational, non-interventional, 24-week post-marketing surveillance study in Japanese patients with type 2 diabetes (T2DM) having uncontrolled glycemic control, demonstrated that basal supported oral therapy (BOT) with insulin glargine was an effective and safe treatment in real-life clinical practice. We performed subgroup an...

OBJECTIVE In recent years, there has been an ongoing discussion on the relationship between diabetes and driving. As driving performance will inevitably decline at lower levels of glycemia, patients' decisions concerning driving or taking corrective action when hypoglycemia occurs immediately before or during driving seems paramount. RESEARCH DESIGN AND METHODS Twenty-four type 1 diabetic pat...

Diabetes mellitus is a global medical and social issue. In the developed countries of world, from 5 to 12% population are diagnosed with diabetes and, according WHO prognosis, level this disease may increase 30-35%. Type 2 that progresses over time, but rational systematic use hypoglycemic synthetic drugs phytopreparations can significantly delay onset insulin therapy. A promising source BAS ef...

OBJECTIVE The purpose of this study was to test the hypothesis that changing utilization of lipid-lowering, antihypertensive, and oral hypoglycemic drugs may be associated with trends in all-cause mortality in men and women with type 2 diabetes. RESEARCH DESIGN AND METHODS This was a cohort study in 197 general practices in the U.K. General Practice Research Database including 48,579 subjects...