Introduction: Verrucous carcinoma is a non-metastatic variant of squamous cell carcinoma. It was first reported by Ackerman in 1948. verrucous exophytic tumor and, although it rare lesion, mainly affects the oral cavity, with slow growth and can be locally invasive. Objective: To report case present an observational retrospective analysis medical records containing biopsy data from patients dia...

Cajanus cajan (L.) Millsp., known as pigeon pea, C. Millsp. roots (CR) contain daidzein, genistein, and cajanol which have numerous health benefits. The aim of this study was to investigate the anti-proliferative anti-metastatic effects sub-fractions (EECRpw, EECRp25, EECRp50, EECRp70, EECRp95) containing 95% ethanol extract from CR (EECR95) in oral squamous cell carcinoma cells (SCC25). We fou...

We have previously shown that a stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis, but not in that of distant metastasis, in oral squamous cell carcinoma (SCC). In this study, we investigated the role of the autocrine SDF-1/CXCR4 system, with a focus on distant metastasis in oral SCC cells. The immunohistochemical staining of SD...

Background Recently, transoral endoscopic thyroidectomy via the vestibular approach (TOETVA) has become popular worldwide.1–3 After controlling for technique, authors used to modified radical neck dissection (MRND) papillary thyroid carcinoma with clinically positive lymph nodes in lateral compartments. To best of their knowledge, report first case TOETVA MRND. Patient A 27-year-old woman had a...

colloid carcinoma, also called mucinous carcinoma, is classified as a histologic variant of adenocarcinoma. because the colloid carcinoma of the biliary tree is exceedingly rare, the imaging characteristics and the clinical features of colloid carcinoma remain relatively unknown. we report a case of colloid carcinoma of the common bile duct and its accompanied metastatic lymphadenopathies with ...

BACKGROUND A Phase II study was initiated to evaluate the effectiveness of an oral regimen of etoposide and estramustine in patients with early recurrent prostate carcinoma. METHODS Patients with early recurrent prostate carcinoma as indicated by an increasing prostate specific antigen (PSA) level and without any evidence of metastatic disease were treated with oral etoposide 50 mg/m2/day and...

Adenoid cystic carcinoma (ACC) is a rare cancer, and there are no standard-of-care treatments for patients with metastatic ACC. We herein report a patient with lung metastasis of ACC who achieved a favorable response to levetiracetam. A 52-year-old Japanese man was admitted to our hospital because of multiple lung metastases of ACC. We performed first-line chemotherapy with cisplatin plus gemci...

Abstract Aim The present review article aims to compile the best available evidence-based data on oral metronomic chemotherapy (OMCT) including its mechanism of action, utility, and future directions. Methods A systematic search was carried out in PubMed database for English literature from last 10 years between 2011 2021. Keyword combinations used were ‘Oral Metronomic cancer, action OMCT, Ora...

Von Hippel-Lindau (VHL) disease is an autosomal dominant disease that produces a variety of tumors and cysts in the central nervous system and visceral organs, including renal cell carcinoma (RCC). RCC in patients with VHL disease does not frequently metastasize, therefore, the response to treatment and prognosis of metastatic RCC developed in patients with VHL disease has not been reported. Su...