INTRODUCTION Because the use of procalcitonin (PCT) as a marker of bacterial infection has been advocated, this study was carried out to determine the usefulness of plasma PCT in the early diagnosis and differentiation of patients with non-infectious systemic inflammatory response syndrome (SIRS) from those with sepsis, and the relationship between plasma PCT level and severity of organ failure...

In this editorial the dominant sites of organ manifestations in hereditary haemochromatosis are discussed as well as conditions that can occur as a result of iron-mediated manifestations: liver disease, diabetes mellitus, arthritis, and cardiomyopathy. The incidences of these organ manifestations and their well-known typical symptomatology are mentioned, in order to investigate hereditary haemo...

Critical condition, developing in patients with burns during the burn shock more often produce the development of nonspecific reactions in the body, manifested as the system or the organ insufficiency and are determined by the term «syndrome of poly organ insufficiency» (SPOI). The course and treatment of 189 patients with burn shock have been analyzed. With the purpose of investigation all pat...

Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated infla...

Allergen specific immunotherapy (ASI) is a well-documented treatment for allergic asthma, rhinitis and allergy to bee venoms. Immunotherapy with subcutaneous injections of allergens extracts has proved beneficial in reducing symptoms of allergic rhinitis and asthma. Side effects due to specific immunotherapy in short term have been largely documented. These effects were various but were usually...

In the last 5 years, the understanding of the epidemiology and pathogenesis of pediatric sepsis, septic shock, and multiple organ failure has expanded greatly. There has also been a substantial increase in the number of successful randomized trials in which success has been measured as reduction in mortality in adults, children, and newborns. This article discusses these advances, updating the ...

Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. It is strongly related to number of systems with failure, type of system involved, risk factors such as age, previous chronic diseases, delayed or inadequate resuscitation, persistent infection, immune suppression, and others. The prognoses is worse for patients rather than in elective or emer...

Brandon Libby1*, Anne-Michelle Ruha2, Robert Raschke3 and Mark Wong4 1Department of Emergency Medicine, Boston University/Boston Medical Center, USA 2Department of Medical Toxicology, University of Arizona College of Medicine/Banner Good Samaritan Medical Center, USA 3Department of Critical Care Medicine, University of Arizona College of Medicine/Banner Good Samaritan Medical Center, USA 4Depar...

Ischemia signifies failure to satisfy the metabolic needs of the cell secondary to either impaired oxygen delivery or the impairment of cellular oxygen extraction and utilization. Incomplete splanchnic cellular resuscitation has been associated with the development of multiple organ system failure and increased mortality in the critically ill patient (1,2). For many years, the merits of augment...